Long-term use of a neural prosthesis in progressive paralysis.
Long-term use of a neural prosthesis in progressive paralysis.
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DOI：
10.1038/s41598-018-35211-y
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发表时间：
2018-11-14
影响因子：
4.6
通讯作者：
Kansaku K
中科院分区：
文献类型：
--
作者：
Okahara Y;Takano K;Nagao M;Kondo K;Iwadate Y;Birbaumer N;Kansaku K
脑机接口(BCI)实现了与他人的通信，并允许在没有运动活动的情况下控制机器或计算机。已有临床研究评估肌萎缩侧索硬化症(ALS)患者的神经假体；然而，到目前为止，还没有研究报道ALS患者从自主运动非常有限的锁定综合征(LIS)发展到以完全丧失自主运动为特征的完全锁定状态(CLI)，能够继续控制神经假体。为了阐明这一点，我们使用BCI系统对三名晚期ALS患者进行了27个月的评估。我们利用闪烁的绿色和蓝色发光二极管产生的稳态视觉诱发脑电位来控制脑机接口系统。所有参与者在整个过程中都可靠地控制了系统(中位数准确率：83.3%)。一名进展到CLIS的患者能够继续以高精度操作该系统。此外，这名患者成功地使用该系统回答了是/否的问题。因此，这位CLIS患者能够操作神经假体设备，这表明BCI系统为重度瘫痪患者提供了优势，包括那些肌肉运动完全丧失的患者。
Brain–computer interfaces (BCIs) enable communication with others and allow machines or computers to be controlled in the absence of motor activity. Clinical studies evaluating neural prostheses in amyotrophic lateral sclerosis (ALS) patients have been performed; however, to date, no study has reported that ALS patients who progressed from locked-in syndrome (LIS), which has very limited voluntary movement, to a completely locked-in state (CLIS), characterized by complete loss of voluntary movements, were able to continue controlling neural prostheses. To clarify this, we used a BCI system to evaluate three late-stage ALS patients over 27 months. We employed steady-state visual evoked brain potentials elicited by flickering green and blue light-emitting diodes to control the BCI system. All participants reliably controlled the system throughout the entire period (median accuracy: 83.3%). One patient who progressed to CLIS was able to continue operating the system with high accuracy. Furthermore, this patient successfully used the system to respond to yes/no questions. Thus, this CLIS patient was able to operate a neuroprosthetic device, suggesting that the BCI system confers advantages for patients with severe paralysis, including those exhibiting complete loss of muscle movement.
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影响因子：
9.9
作者：
Gallegos-Ayala G;Furdea A;Takano K;Ruf CA;Flor H;Birbaumer N
通讯作者：
Birbaumer N
DOI：
10.1016/j.clinph.2008.06.019
发表时间：
2008-11
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Kübler A;Birbaumer N
通讯作者：
Birbaumer N
影响因子：
2.4
作者：
Acharya, Jayant N.;Hani, Abeer;Tsuchida, Tammy N.
通讯作者：
Tsuchida, Tammy N.
影响因子：
2.5
作者：
Fuchino, Yutaka;Nagao, Masahiro;Yoro, Takeshi
通讯作者：
Yoro, Takeshi
影响因子：
4
作者：
Bensch, Michael;Martens, Suzanne;Gharabaghi, Alireza
通讯作者：
Gharabaghi, Alireza