Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans.
Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans.
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DOI：
10.1016/j.neuropharm.2013.02.015
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发表时间：
2014-09
影响因子：
4.7
通讯作者：
Stein EA
中科院分区：
文献类型：
--
作者：
Jasinska AJ;Zorick T;Brody AL;Stein EA
大量证据表明尼古丁的成瘾倾向和它的认知增强作用。然而，尼古丁对大脑功能和行为影响的神经生物学机制仍不完全清楚。阐明这些机制具有高度的临床重要性，并可能导致戒烟以及许多认知障碍如精神分裂症的治疗方法的改进。正电子发射断层扫描（PET）、单光子发射计算机断层扫描（SPECT）和功能性磁共振成像（fMRI）等神经成像技术使研究尼古丁在人体大脑中的作用成为可能，在识别这些双重作用机制方面发挥着越来越重要的作用。在这篇综述中，我们总结了目前的知识状态，并讨论了突出的问题和未来的方向，在人类神经影像学研究尼古丁和烟草。这项研究涵盖了受体水平的PET和SPECT研究，证明尼古丁在烟碱乙酰胆碱受体（nAChR）上的占有率和慢性吸烟诱导的nAChR上调;通过尼古丁与中皮质边缘多巴胺系统的相互作用，据信介导尼古丁的强化作用，导致依赖;功能活动和连接功能磁共振成像研究记录尼古丁的复杂的行为和认知影响，表现在它的行动大-在执行任务和休息时都参与的大脑网络。
Substantial evidence demonstrates both nicotine’s addiction liability and its cognition-enhancing effects. However, the neurobiological mechanisms underlying nicotine’s impact on brain function and behavior remain incompletely understood. Elucidation of these mechanisms is of high clinical importance and may lead to improved therapeutics for smoking cessation as well as for a number of cognitive disorders such as schizophrenia. Neuroimaging techniques such as positron emission tomography (PET), single photon emission computed tomography (SPECT), and functional magnetic resonance imaging (fMRI), which make it possible to study the actions of nicotine in the human brain in vivo, play an increasingly important role in identifying these dual mechanisms of action. In this review, we summarize the current state of knowledge and discuss outstanding questions and future directions in human neuroimaging research on nicotine and tobacco. This research spans from receptor-level PET and SPECT studies demonstrating nicotine occupancy at nicotinic acetylcholine receptors (nAChRs) and upregulation of nAChRs induced by chronic smoking; through nicotine’s interactions with the mesocorticolimbic dopamine system believed to mediate nicotine’s reinforcing effects leading to dependence; to functional activity and connectivity fMRI studies documenting nicotine’s complex behavioral and cognitive effects manifest by its actions on large-scale brain networks engaged both during task performance and at rest.
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DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
影响因子：
--
作者：
Brody, Arthur L.;Mandelkern, Mark A.;Mukhin, Alexey G.
通讯作者：
Mukhin, Alexey G.
吸烟者和非吸烟者的纹状体多巴胺D2/D3受体可用性的性别差异。
DOI：
10.1017/s1461145711001957
发表时间：
2012-08
期刊：
The international journal of neuropsychopharmacology
影响因子：
--
作者：
Brown AK;Mandelkern MA;Farahi J;Robertson C;Ghahremani DG;Sumerel B;Moallem N;London ED
通讯作者：
London ED
影响因子：
4.7
作者：
BENWELL, MEM;BALFOUR, DJK;ANDERSON, JM
通讯作者：
ANDERSON, JM
影响因子：
2.3
作者：
Barrett, SP;Boileau, I;Dagher, A
通讯作者：
Dagher, A