The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes.
The newly proposed Metabolic Score for Visceral Fat is a reliable tool for identifying non-alcoholic fatty liver disease, requiring attention to age-specific effects in both sexes.
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DOI：
10.3389/fendo.2023.1281524
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发表时间：
2023
影响因子：
5.2
通讯作者：
中科院分区：
文献类型：
--
作者：
新提出的代谢内脏脂肪评分（METS-VF）被认为是比其他肥胖指标更有效的内脏脂肪组织（VAT）衡量标准。本研究旨在揭示 METS-VF 与非酒精性脂肪肝 (NAFLD) 之间的关联，及其在两性年龄组中的差异。本研究采用了 NAGALA 项目中 14,251 名体检医师的数据。基于多元逻辑回归模型构建 3D 拟合曲面图，以可视化衰老和 METS-VF 对 NAFLD 的单独影响和综合影响。进行受试者工作特征曲线（ROC）分析，比较 METS-VF 与其他 VAT 替代标志物在预测 NAFLD 方面的诊断性能。多变量逻辑回归分析结果显示，METS-VF 每增加一个单位，男性和女性患 NAFLD 的几率分别增加 333% 和 312%。此外，3D拟合曲面图显示，年龄显着影响两性中METS-VF与NAFLD发生率之间的关联，如下：（i）在男性中，当METS-VF小于6.2时，20-45岁年龄组中METS-VF相关的NAFLD发生率随着年龄逐渐增加，在45-65岁年龄组中达到平台，然后在65岁以上组中下降；然而，当男性 METS-VF 超过 6.2 时，衰老和 METS-VF 结合起来，进一步增加了所有年龄组，特别是 45-65 岁年龄组患 NAFLD 的几率。 (ii) 在女性中，衰老似乎降低了 18-40 岁年龄组中与 METS-VF 相关的 NAFLD 几率，但在 40-60 岁年龄组中显着增加，特别是对于那些 METS-VF 水平较高的女性。进一步的 ROC 分析显示，与其他 VAT 替代标志物相比，METS-VF 对女性 NAFLD 的诊断准确性最高，尤其是 45 岁以下的女性 [曲线下面积 (AUC) = 0.9256]。本研究首次揭示了 METS-VF 与 NAFLD 发生率之间存在显着的正相关性，且 METS-VF 在 NAFLD 诊断中优于其他 VAT 替代标志物。此外，年龄显着影响 METS-VF 相关的 NAFLD 几率以及 METS-VF 对男女 NAFLD 的诊断功效。
The newly proposed Metabolic Visceral Fat Score (METS-VF) is considered a more effective measure for visceral adipose tissue (VAT) than other obesity indicators. This study aimed to reveal the association between METS-VF and non-alcoholic fatty liver disease (NAFLD), and its variations across age groups within both sexes. Data from 14,251 medical examiners in the NAGALA project were employed in this study. 3D fitted surface plots were constructed based on multivariate logistic regression models to visualize the isolated and combined effects of aging and METS-VF on NAFLD. Receiver operating characteristic curve (ROC) analysis was conducted to compare the diagnostic performance of METS-VF with other VAT surrogate markers in predicting NAFLD. The results of multivariate logistic regression analysis showed that each unit increase in METS-VF was independently associated with a 333% and 312% increase in the odds of NAFLD in males and females, respectively. Additionally, the 3D fitted surface plot showed that age significantly influenced the association between METS-VF and the odds of NAFLD in both sexes, as follows: (i) In males, when METS-VF was less than 6.2, the METS-VF-related odds of NAFLD increased gradually with age in the 20-45 age group, reached a plateau in the 45-65 age group, and then decreased in the group above 65 years old; however, when male METS-VF exceeded 6.2, aging and METS-VF combined to further increase the odds of NAFLD in all age groups, particularly in the 45-65 age group. (ii) In females, aging seemed to reduce METS-VF-related odds of NAFLD in the 18-40 age group, but significantly increased it in the 40-60 age group, particularly for those with higher METS-VF levels. Further ROC analysis revealed that compared to other VAT surrogate markers, METS-VF showed the highest diagnostic accuracy for NAFLD in females, especially in those under 45 years of age [area under the curve (AUC) = 0.9256]. This study firstly revealed a significant positive correlation between METS-VF and the odds of NAFLD, with METS-VF surpassing other VAT surrogate markers in NAFLD diagnosis. Moreover, age significantly influenced the METS-VF-related odds of NAFLD and METS-VF’s diagnostic efficacy for NAFLD in both sexes.
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影响因子：
3.8
作者：
Ballestri S;Nascimbeni F;Baldelli E;Marrazzo A;Romagnoli D;Lonardo A
通讯作者：
Lonardo A
影响因子：
2.9
作者：
Fishbein, M;Castro, F;Stevens, WR
通讯作者：
Stevens, WR
DOI：
10.1016/j.numecd.2020.06.001
发表时间：
2020-09-24
影响因子：
3.9
作者：
Liu, Xing Z.;Chen, Dong S.;Fan, Jie
通讯作者：
Fan, Jie
影响因子：
2.9
作者：
Kim, Jong Hae
通讯作者：
Kim, Jong Hae
影响因子：
--
作者：
Jura, Magdalena;Kozak, Leslie. P.
通讯作者：
Kozak, Leslie. P.