The effects of environmental factors associated with childhood urbanicity on brain structure and cognition.
The effects of environmental factors associated with childhood urbanicity on brain structure and cognition.
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DOI：
10.1186/s12888-023-05066-3
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发表时间：
2023-08-17
期刊：
影响因子：
4.4
通讯作者：
Yue, Weihua
中科院分区：
文献类型：
--
作者：
Zhang, Xiao;Yan, Hao;Yu, Hao;Zhang, Yuyanan;Tan, Hao Yang;Zhang, Dai;Yue, Weihua
城市化是世界范围内持续了一个多世纪的趋势。本研究包括490名不同城市和农村童年的成年中国汉族人，男女各半。早期城市环境有利于灰质总体积(GMV)、背外侧前额叶(DLPFC)GMV、颞极(TP)GMV和认知功能，与内侧前额叶(MPFC)GMV呈负相关。回归分析显示，母亲文化程度是总GMV和DLPFC GMV的保护因素，而有兄弟姐妹对MPFC GMV的保护作用更好。TOTAL、DLPFC和TP GMVS在儿童都市性与不同认知领域之间起中介作用。这些发现可能表明大脑结构与儿童都市性和相关环境因素有关的一些利弊。网上版载有补充材料，可在10.1186/s12888-023-05066-3查阅。城市化是一个多世纪的趋势，我们深入研究了具体环境因素对大脑结构和认知功能的影响。早期农村环境有利于内侧前额叶皮质灰质体积(GMV)，有兄弟姐妹是MPFC GMV的保护因素。早期都市化对认知功能和整个前额叶皮质及背外侧前额叶皮质的GMV均有改善作用，母亲教育是其保护因素。TOTAL、DLPFC和TP GMVS在儿童都市性与不同认知领域之间起中介作用。网上版载有补充材料，可在10.1186/s12888-023-05066-3查阅。
Urbanization is a trend lasting for more than one century worldwide. Four hundred ninety male and female adult Chinese Han participants with different urban and rural childhoods were included in this study. Early-life urban environment was found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed that maternal education was a protective factor for total and DLPFC GMVs, while having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. These findings may suggest some pros and cons on brain structure associated with childhood urbanicity and related environmental factors. The online version contains supplementary material available at 10.1186/s12888-023-05066-3. Urbanization is a trend lasting for more than one century, we did in-depth research which specific environment factor affects the brain structure and cognition function. Early-life rural environment was benefit for the grey matter volume (GMV) of medial prefrontal cortex, having siblings was a protective factor for MPFC GMV. Early-life urbanicity was benefit for cognition function and the GMV of total and dorsolateral prefrontal cortex, of which maternal education was a protective factor. Total, DLPFC and TP GMVs acts mediation effects between childhood urbanicity and different cognitive domains. The online version contains supplementary material available at 10.1186/s12888-023-05066-3.
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影响因子：
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DOI：
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发表时间：
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