Brain metabolism in hepatic encephalopathy and hyperammonemia.

Brain metabolism in hepatic encephalopathy and hyperammonemia.
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肝性脑病和高氨血症中的脑代谢。

DOI:
10.1007/978-1-4615-2484-7_2
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发表时间:
1993
影响因子:
--
通讯作者:
Mans,AM
Mans,AM
中科院分区:
医学4区
文献类型:
--
作者:
Hawkins,RA;Mans,AM

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在美国,肝衰竭是25-65岁人群的第六大死因。肝功能衰竭可能在几天内发生,作为暴发性肝坏死的结果,或在多年的慢性疾病,如酒精性脂肪肝或肝硬化。当肝脏衰竭时,或者当血液绕过坏死的肝脏直接从肠道进入体循环时,脑功能恶化:一种称为肝性脑病的疾病[1,18,36,47,53]。该综合征表现为从暴发性肝坏死中迅速发展的谵妄、惊厥和昏迷序列到慢性肝病患者中可能导致木僵和昏迷的逐渐发展的智力障碍。后一种形式更为普遍,可能在某种程度上影响数百万人[34,441]。
In the United States of America liver failure is the sixth leading cause of death in persons aged 25–65 years. Liver failure may occur within days as a result of fulminant hepatic necrosis or over many years in chronic conditions such as alcoholic fatty liver or cirrhosis. When the liver fails, or when blood is shunted around a cirrhotic liver directly from the intestines into the systemic circulation, brain function deteriorates: a disorder known as hepatic encephalopathy [1,18, 36,47, 53]. This syndrome is manifest by signs that range from a rapidly developing sequence of delirium, convulsions and coma in fulminant hepatic necrosis to a more gradually developing intellectual impairment that may lead to stupor and coma in patients with chronic liver disease. The latter form is more prevalent and may affect several millions of people to some degree [34, 441].
脑脊液谷氨酰胺作为肝性脑病的衡量标准。
DOI: 10.1001/archinte.1971.00310180049005
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