Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial.
Effects of aerobic and resistance training on hemoglobin A1c levels in patients with type 2 diabetes: a randomized controlled trial.
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DOI：
10.1001/jama.2010.1710
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发表时间：
2010-11-24
影响因子：
120.7
通讯作者：
Earnest, Conrad P.
中科院分区：
文献类型：
--
作者：
Church, Timothy S.;Blair, Steven N.;Cocreham, Shannon;Johannsen, Neil;Johnson, William;Kramer, Kimberly;Mikus, Catherine R.;Myers, Valerie;Nauta, Melissa;Rodarte, Ruben Q.;Sparks, Lauren;Thompson, Angela;Earnest, Conrad P.
糖尿病患者的运动指南包括有氧和阻力训练，尽管很少有研究直接检查这种运动组合。在2型糖尿病患者中，检查单独有氧训练、单独阻力训练以及两者结合对血红蛋白A1 c（HbA 1c）的益处。一项随机对照试验，其中262名患有2型糖尿病且HbA 1c水平为6.5%或更高的路易斯安那州久坐男性和女性在2007年4月至2009年8月期间参加了为期9个月的运动计划。41名参与者被分配到非运动对照组，73名每周进行3天阻力训练，72名每周消耗12千卡/千克的有氧运动; 76名每周消耗10千卡/千克的有氧和阻力训练相结合，每周进行两次阻力训练。HbA 1c水平变化。次要结果包括人体测量和健身措施。该研究包括63.0%的女性和47.3%的非白人参与者，平均（SD）年龄为55.8岁（8.7岁），基线HbA 1c水平为7.7%（1.0%）。与对照组相比，联合训练运动组HbA 1c的绝对平均变化为−0.34%（95%置信区间“CI”，−0.64%至−0.03%; P= 0.03）。与对照组相比，阻力训练组（−0.16%; 95% CI，−0.46%至0.15%; P= 0.32）或有氧训练组（−0.24%; 95% CI，−0.55%至0.07%; P= 0.14）的HbA 1c平均变化均无统计学显著性。与对照组相比，只有联合运动组改善了最大耗氧量（平均1.0 mL/kg/min; 95% CI，0.5-1.5，P<0.05）。与对照组相比，所有运动组的腰围都从-1.9厘米减少到-2.8厘米。与对照组相比，阻力训练组的平均脂肪量减少了-1.4 kg（95%CI，-2.0至-0.7 kg; P<.05），组合训练组的平均脂肪量减少了-1.7 kg（-2.3至-1.1 kg; P<.05）。在2型糖尿病患者中，与非运动对照组相比，有氧和阻力训练的组合改善了HbA 1c水平。这并不是仅仅通过有氧或阻力训练就能实现的。
Exercise guidelines for individuals with diabetes include both aerobic and resistance training although few studies have directly examined this exercise combination. To examine the benefits of aerobic training alone, resistance training alone, and a combination of both on hemoglobin A1c (HbA1c) in individuals with type 2 diabetes. A randomized controlled trial in which 262 sedentary men and women in Louisiana with type 2 diabetes and HbA1c levels of 6.5% or higher were enrolled in the 9-month exercise program between April 2007 and August 2009. Forty-one participants were assigned to the nonexercise control group, 73 to resistance training 3 days a week, 72 to aerobic exercise in which they expended 12 kcal/kg per week; and 76 to combined aerobic and resistance training in which they expended 10 kcal/kg per week and engaged in resistance training twice a week. Change in HbA1c level. Secondary outcomes included measures of anthropometry and fitness. The study included 63.0% women and 47.3% nonwhite participants who were a mean (SD) age of 55.8 years (8.7 years) with a baseline HbA1c level of 7.7% (1.0%). Compared with the control group, the absolute mean change in HbA1c in the combination training exercise group was −0.34% (95% confidence interval “CI”, −0.64% to −0.03%; P=.03). The mean changes in HbA1c were not statistically significant in either the resistance training (−0.16%; 95% CI, −0.46% to 0.15%; P=.32) or the aerobic (−0.24%; 95% CI, −0.55% to 0.07%; P=.14) groups compared with the control group. Only the combination exercise group improved maximum oxygen consumption (mean, 1.0 mL/kg per min; 95% CI, 0.5-1.5, P<.05) compared with the control group. All exercise groups reduced waist circumference from −1.9 to −2.8 cm compared with the control group. The resistance training group lost a mean of −1.4 kg fat mass (95% CI, −2.0 to −0.7 kg; P<.05) and combination training group lost a mean of −1.7 (−2.3 to −1.1 kg; P<.05) compared with the control group. Among patients with type 2 diabetes mellitus, a combination of aerobic and resistance training compared with the nonexercise control group improved HbA1c levels. This was not achieved by aerobic or resistance training alone.
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