Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts.
Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts.
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DOI：
10.1016/j.jbiomech.2013.10.041
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发表时间：
2014-06-27
影响因子：
2.4
通讯作者：
Athanasiou, Kyriacos A.
中科院分区：
文献类型：
--
作者：
Cissell, Derek D.;Hu, Jerry C.;Griffiths, Leigh G.;Athanasiou, Kyriacos A.
异种组织来源于其他动物物种，并提供用于工程化机械功能组织移植物（如心脏瓣膜、肌腱、韧带和软骨）的材料来源。然而，异种组织含有称为抗原的分子，这些分子在植入患者体内后引起免疫反应。因此，有必要从异种组织中去除抗原以防止移植物的免疫排斥。抗原去除可以通过用溶液和/或破坏细胞并溶解、降解或掩蔽抗原的物理过程处理组织来实现。然而，用于从组织中去除细胞和抗原的过程通常对组织的细胞外基质（ECM）具有有害影响，使得组织由于差的机械性能而不适合植入。因此，抗原去除过程的目标应该是减少异种组织的抗原含量，同时保留其机械功能。为了扩大去除抗原的异种组织作为生物力学功能移植物的临床应用，研究人员必须检查组织抗原含量，ECM组成和结构以及新的抗原去除过程的机械性能。
Xenogeneic tissues are derived from other animal species and provide a source of material for engineering mechanically functional tissue grafts, such as heart valves, tendons, ligaments, and cartilage. Xenogeneic tissues, however, contain molecules, known as antigens, which invoke an immune reaction following implantation into a patient. Therefore, it is necessary to remove the antigens from a xenogeneic tissue to prevent immune rejection of the graft. Antigen removal can be accomplished by treating a tissue with solutions and/or physical processes that disrupt cells and solubilize, degrade, or mask antigens. However, processes used for cell and antigen removal from tissues often have deleterious effects on the extracellular matrix (ECM) of the tissue, rendering the tissue unsuitable for implantation due to poor mechanical properties. Thus, the goal of an antigen removal process should be to reduce the antigen content of a xenogeneic tissue while preserving its mechanical functionality. To expand the clinical use of antigen-removed xenogeneic tissues as biomechanically functional grafts, it is essential that researchers examine tissue antigen content, ECM composition and architecture, and mechanical properties as new antigen removal processes are developed.
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