Self-reported teenage body size and heart failure in adults ≥65years of age.
Self-reported teenage body size and heart failure in adults ≥65years of age.
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自我报告的青少年身体尺寸和 65 岁以上成年人的心力衰竭。
DOI：
10.1016/j.ijcard.2011.03.029
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发表时间：
2011
影响因子：
3.5
通讯作者：
Ahmed,Ali
中科院分区：
文献类型：
--
作者：
Levitan,EmilyB;Mujib,Marjan;Feller,MargaretA;Jones,LindaG;Sawyer,Patricia;Anker,StefanD;Ahmed,Ali
儿童期和青年期超重与成年后期全因和心血管死亡率较高相关[1-4]。然而，生命早期的体型与成年后期心力衰竭（HF）发生率之间的关系尚不清楚。我们假设，青少年早期（11-14岁）自我报告的大于平均身高的青少年体型与成年后较高的HF发病率相关。我们在社区居住老年人队列中检验了这一假设。心血管健康研究（CHS）包括1989年至1993年从美国4个地区招募的5，888名符合医疗保险条件的≥ 65岁社区居住成年人[5]。CHS由国家心肺和血液研究所（NHLBI）与CHS研究者合作进行和支持。本手稿是使用从NHLBI获得的限制访问数据集编写的，不一定反映CHS或NHLBI的意见或观点。在排除了不同意纳入限制访问数据集的参与者（n= 93），基线时患有HF的参与者（n= 274）以及自报青少年体型（n= 210）或基线体重指数（n= 18）缺失数据的参与者后，5，293名CHS参与者被纳入当前分析。社区卫生服务的设计和实施得到了参与的外地中心的机构审查委员会的批准。参与者提供了知情同意书。
Overweight during childhood and young adulthood has been associated with higher rates of all-cause and cardiovascular mortality in later adulthood [1-4]. However, the relationship between body size in early life and incidence of heart failure (HF) in later adulthood is not known. We hypothesized that self-reported heavier-than-average teenage body size as an early teenager (ages 11-14) would be associated with a higher rate of incident HF in adulthood. We examined this hypothesis in a cohort of community dwelling older adults.Cardiovascular Health Study (CHS) includes 5,888 Medicare-eligible, community dwelling adults≥ 65 years of age who were recruited between 1989 and 1993 from 4 areas in the US [5]. The CHS is conducted and supported by the Nation Heart Lung and Blood Institute (NHLBI) in collaboration with the CHS Study Investigators. This manuscript was prepared using a limited access dataset obtained from the NHLBI and does not necessarily reflect the opinions or views of the CHS or the NHLBI. After excluding participants who did not consent to being included in the limited access dataset (n= 93), those who had HF at baseline (n= 274), and those with missing data on self-reported teenage body size (n= 210) or baseline body mass index (n= 18), 5,293 CHS participants were included in the current analyses. The design and conduct of the CHS was approved by institutional review boards at the participating field centers. Participants provided informed consent.
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影响因子：
8
作者：
R. Lauer;W. Clarke
通讯作者：
R. Lauer;W. Clarke
影响因子：
7.1
作者：
Gunnell, DJ;Frankel, SJ;Smith, GD
通讯作者：
Smith, GD
影响因子：
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作者：
Srinivasan, SR;Bao, WH;Berenson, GS
通讯作者：
Berenson, GS
影响因子：
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作者：
Ives, Diane G.;Fitzpatrick, Annette L.;Theroux, Sharene
通讯作者：
Theroux, Sharene