The influence of social support on hematopoietic stem cell transplantation survival: a systematic review of literature.
The influence of social support on hematopoietic stem cell transplantation survival: a systematic review of literature.
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DOI：
10.1371/journal.pone.0061586
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Tay J
中科院分区：
文献类型：
--
作者：
Beattie S;Lebel S;Tay J
造血干细胞移植（HSCT）可能会对患者的心理健康产生负面影响。社会支持是一个复杂的术语，已被广泛用于包括感知和客观的支持，包括照顾者的存在。社会支持与上级心理社会结果相关;然而，社会支持对HSCT生存率的影响仍不清楚。我们试图总结有关社会支持对造血干细胞移植生存率影响的文献。使用以下检索类别/概念检索Medline、EMBASE、科克伦、CINAHL和PsycINFO：1）HSCT、2）社会支持、3）护理者、4）生存和5）治疗结局。我们确定了6项相关研究：4篇出版物，1篇论文和1篇摘要。3项研究为回顾性，3项为前瞻性。样本量范围为92-272例，平均/中位患者年龄为30-55岁。随访时间为13.3-48个月。社会支持的测量不一致：2例通过回顾性研究者评估，2例作为患者感知的支持，1例作为护理人员的存在，1例包括护理人员的存在和回顾性研究者评估。4项已发表的研究和1项摘要表明，更好的社会支持与生存之间存在关联。然而，未发表的论文，最大的样本量发现没有关联。有一个缺乏的证据检查HSCT生存的社会支持。现有的研究报告年代较早，最近一次出版是在2005年。研究了一组异质性HSCT患者，随访时间不同。此外，协变量在HSCT生存分析中被反复考虑，我们认为可能存在发表偏倚，因为阴性的未发表研究样本量最大。有必要使用经过验证的量表进行前瞻性研究，以更好地评估社会支持对HSCT死亡率的影响。考虑到在更好的社会支持下提高HSCT生存率的潜力，HSCT中心应定期为HSCT接受者及其护理人员提供增强的心理社会服务。
Hematopoietic Stem cell Transplantation (HSCT) can negatively impact the psychosocial well-being of the patient. Social support is a complex term that has been variably used to encompass perceived and objective support, including caregiver presence. Social support has been associated with superior psychosocial outcomes; however the influence of social support on HSCT survival remains unclear. We sought to summarize the literature on the influence of social support on HSCT survival. Medline, EMBASE, Cochrane, CINAHL, and PsycINFO were searched using the following search categories/concepts: 1) HSCT, 2) Social support, 3) Caregiver, 4) Survival, and 5) Treatment outcomes. We identified 6 relevant studies: 4 publications, 1 dissertation, and 1 abstract. Three studies were retrospective and 3, prospective. Sample size ranged between 92–272 with a mean/median patient age between 30–55 yrs. The duration of follow-up ranged between 13.3–48 months. Social support was measured inconsistently: 2 by retrospective investigator assessment, 2 as patients’ perceived support, 1 as caregiver presence, and 1 included caregiver presence and retrospective investigator assessment. The 4 published studies and 1 abstract demonstrate an association between better social support and survival. However, the unpublished dissertation, with the largest sample size found no association. There is a paucity of evidence examining social support with HSCT survival. Available studies are older, with the most recent publication in 2005. A heterogeneous group of HSCT patients were studied with variable follow-up times. Further, covariates were variably considered in HSCT survival analyses and we suggest that there may be publication bias, given the negative unpublished study with the largest sample size. Prospective studies using validated scales are necessary to better assess the influence of social support on HSCT mortality. Given the potential for improved HSCT survival with better social support, HSCT centres should routinely provide HSCT recipients and their caregivers with enhanced psychosocial services.
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