Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity.
Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity.
复制标题
溃疡性结肠炎中性粒细胞自身抗体：家族聚集和遗传异质性。
DOI：
10.1016/0016-5085(92)90834-l
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发表时间：
1992
期刊：
影响因子：
29.4
通讯作者：
Targan,SR
中科院分区：
文献类型：
--
作者：
Shanahan,F;Duerr,RH;Rotter,JI;Yang,H;Sutherland,LR;McElree,C;Landers,CJ;Targan,SR
中性粒细胞自身抗体与溃疡性结肠炎相关的可能性，代表易感性的遗传标记进行了调查，确定其患病率在未受影响的亲属的患者。采用酶联免疫吸附试验检测中性粒细胞自身抗体，并通过间接免疫荧光证实阳性值。先证者（68%，26/38）及其家族成员（15.7%，17/108）中性粒细胞抗体阳性率均高于对照组（2.9%，1/35）（分别为P< 0.0001和P <0.05）。这些结果与来自第二个中心的血清证实，其中86.4%（19/22）的先证者为阳性，20.9%（9/43）的亲属为阳性。抗体阳性先证者亲属中性粒细胞自身抗体阳性率（21.4%）显著高于抗体阴性先证者亲属中性粒细胞自身抗体阳性率（7%）（P< 0.05）。这些发现与这些抗体是溃疡性结肠炎遗传易感性的潜在标志物一致，并表明这种疾病中存在遗传异质性的可能性。
The possibility that the neutrophil autoantibodies associated with ulcerative colitis represent a genetic marker of susceptibility was investigated by determining their prevalence in unaffected relatives of patients. Neutrophil autoantibodies were detected using an enzyme-linked immunosorbent assay, and positive values were confirmed by indirect immunofluorescence. An increased prevalence of neutrophil antibodies was found not only in the probands (68%, 26/38) but also in their clinically unaffected family members (15.7%, 17/108) compared with controls (2.9%, 1/35) (P< 0.0001 andP< 0.05,respectively). These results were confirmed with sera from a second center, where 86.4% (19/22) of probands were positive and 20.9% (9/43) of their relatives were positive. The prevalence of neutrophil autoantibodies in the relatives of probands who were antibody positive (21.4%) was significantly greater than the prevalence in relatives of probands who were antibody negative (7%;P< 0.05). The findings are consistent with these antibodies being a potential marker of genetic susceptibility to ulcerative colitis and suggest the possibility of genetic heterogeneity within this disease.
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DOI：
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发表时间：
1990
期刊：
Developments in Gastroenterology
影响因子：
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DOI：
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作者：
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GOLDSCHMEDING, R;VANDERSCHOOT, CE;VONDEMBORNE, AEGK
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