Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment.
Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment.
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DOI：
10.1016/j.neurobiolaging.2017.12.003
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发表时间：
2018-04
影响因子：
4.2
通讯作者：
Krikorian R
中科院分区：
文献类型：
--
作者：
McNamara RK;Kalt W;Shidler MD;McDonald J;Summer SS;Stein AL;Stover AN;Krikorian R
有证据表明二十碳五烯酸、二十二碳六烯酸和富含花青素的蓝莓对神经认知有好处，我们调查了长期补充有认知障碍的老年人。在一项为期24周的随机、双盲、安慰剂对照试验中，老年男性和女性每天服用鱼油(FO)和/或蓝莓(BB)。饮食记录证实，参与者按规定减少了EPA、DHA和花青素的本底摄入量。FO组红细胞EPA+DHA组成增加(p=0.0001)。补充蓝莓后，两组的尿总花青素没有差异，但糖苷和天然(食物)形式增加的只有蓝莓补充组。FO组(p=0.03)和BB组(p=0.05)的认知症状较少，BB组表现出改善的记忆辨别能力(p=0.04)，表明补充营养改善了认知。BB组的认知益处与反映最近BB摄入量的尿花青素的存在有关，但与花青素代谢物无关。然而，FO+BB联合治疗并没有像预期的那样与认知增强有关。
Given evidence that eicosapentaenoic acid, docosahexaenoic acid, and anthocyanin-rich blueberries provide neurocognitive benefit, we investigated long-term supplementation in older adults with cognitive complaints. In a 24-week randomized, double blind, placebo-controlled trial, elderly men and women received daily fish oil (FO) or blueberry (BB) or both. Diet records confirmed that participants reduced background consumption of EPA, DHA, and anthocyanins as prescribed. Erythrocyte EPA+DHA composition increased in the FO groups (p = 0.0001). Total urinary anthocyanins did not differ between the groups after supplementation but glycoside and native (food) forms increased only in the blueberry-supplemented groups. The FO (p = 0.03) and BB (p = 0.05) groups reported fewer cognitive symptoms, and the BB group showed improved memory discrimination (p = 0.04), indicating that supplementation improved cognition. Cognitive benefit in the BB group was associated with the presence of urinary anthocyanins reflecting recent BB intake but not with anthocyanin metabolites. However, combined FO+BB treatment was not associated with cognitive enhancement as expected.
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影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
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作者：
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Subjective Cognitive Decline Initiative (SCD-I) Working Group
DOI：
10.1016/j.jalz.2011.03.008
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
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作者：
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通讯作者：
Phelps CH