A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.

A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease.
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DOI:
10.1016/j.jalz.2014.01.001
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发表时间:
2014-11
期刊:
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子:
--
通讯作者:
Subjective Cognitive Decline Initiative (SCD-I) Working Group
Subjective Cognitive Decline Initiative (SCD-I) Working Group
中科院分区:
其他
文献类型:
--
作者:
Jessen F;Amariglio RE;van Boxtel M;Breteler M;Ceccaldi M;Chételat G;Dubois B;Dufouil C;Ellis KA;van der Flier WM;Glodzik L;van Harten AC;de Leon MJ;McHugh P;Mielke MM;Molinuevo JL;Mosconi L;Osorio RS;Perrotin A;Petersen RC;Rabin LA;Rami L;Reisberg B;Rentz DM;Sachdev PS;de la Sayette V;Saykin AJ;Scheltens P;Shulman MB;Slavin MJ;Sperling RA;Stewart R;Uspenskaya O;Vellas B;Visser PJ;Wagner M;Subjective Cognitive Decline Initiative (SCD-I) Working Group

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越来越多的证据表明,在认知测试中表现未受损的个体中,主观认知下降(SCD)可能代表阿尔茨海默病(AD)的第一个症状表现。然而,由于缺乏统一的标准,对AD早期SCD的研究受到限制。主观认知衰退倡议(SCD-I)的工作组通过就术语和AD中SCD研究的概念框架达成共识来解决这一缺陷。在这篇出版物中,提出了轻度认知障碍(MCI)前期SCD的研究标准。此外,还提供了一份拟议在SCD研究中报告的核心特征清单,这将使不同背景下的研究具有可比性。最后,一组功能,根据目前的知识,增加了临床前AD的存在与SCD的个人的可能性。该列表被称为SCD Plus。
There is increasing evidence that subjective cognitive decline (SCD) in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer’s disease (AD). The research on SCD in early AD, however, is limited by the absence of common standards. The working group of the Subjective Cognitive Decline Initiative (SCD-I) addressed this deficiency by reaching consensus on terminology and on a conceptual framework for research on SCD in AD. In this publication, research criteria for SCD in pre-mild cognitive impairment (MCI) are presented. In addition, a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings. Finally, a set of features is presented, which in accordance with current knowledge, increases the likelihood of the presence of preclinical AD in individuals with SCD. This list is referred to as SCD plus.
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