Normative biometrics for fetal ocular growth using volumetric MRI reconstruction.

Normative biometrics for fetal ocular growth using volumetric MRI reconstruction.
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DOI:
10.1002/pd.4558
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发表时间:
2015-04
期刊:
影响因子:
3
通讯作者:
Warfield, Simon K.
Warfield, Simon K.
中科院分区:
医学2区
文献类型:
--
作者:
Velasco-Annis, Clemente;Gholipour, Ali;Afacan, Onur;Prabhu, Sanjay P.;Estroff, Judy A.;Warfield, Simon K.

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利用体积磁共振成像重建技术确定19 - 38周胎龄(GA)胎儿眼生物特征的标准范围。114个孕周19至38周的健康胎儿的3D图像是通过MRI切片获得的超分辨率体积重建创建的。这些三维图像被半自动分割以测量胎儿眼眶体积、双眼距离(BOD)、眼间距离(IOD)和眼直径(OD)。所有生物计量学均与GA (Volume, CC = 0.9680; BOD, CC = 0.9552; OD, CC = 0.9445; IOD, CC = 0.8429)相关,并按线性和二次生长模型绘制生长曲线。回归分析表明,需氧量、需氧量和需氧量均以二次模型拟合,体积均以线性模型拟合。轨道体积与GA的相关性最大,BOD和OD的相关性也很强。在这项研究中发现的规范性数据可能有助于先天性胎儿异常的检测与更一致的测量比目前可用。
To determine normative ranges for fetal ocular biometrics between 19 and 38 weeks gestational age (GA) using volumetric MRI reconstruction. 3D images of 114 healthy fetuses between 19 and 38 weeks GA were created using super-resolution volume reconstructions from MRI slice acquisitions. These 3D images were semi-automatically segmented to measure fetal orbit volume, binocular distance (BOD), interocular distance (IOD), and ocular diameter (OD). All biometry correlated with GA (Volume, CC = 0.9680; BOD, CC = 0.9552; OD, CC = 0.9445; and IOD, CC = 0.8429), and growth curves were plotted against linear and quadratic growth models. Regression analysis showed quadratic models to best fit BOD, IOD and OD, and a linear model to best fit volume. Orbital volume had the greatest correlation with GA, though BOD and OD also showed strong correlation. The normative data found in this study may be helpful for the detection of congenital fetal anomalies with more consistent measurements than are currently available.
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