Establishing a Thermal Imaging Technology (IRT) Based System for Evaluating Rat Erectile Function.
Establishing a Thermal Imaging Technology (IRT) Based System for Evaluating Rat Erectile Function.
复制标题
建立基于热成像技术（IRT）的大鼠勃起功能评估系统
DOI：
10.1016/j.esxm.2021.100475
复制
发表时间：
2022-03
期刊：
影响因子：
2.6
通讯作者：
Fu Q
中科院分区：
文献类型：
--
作者：
Liu S;Zhao Z;Wang Z;Diao T;Zhang K;Zhang H;Sun D;Kong F;Fu Q
海绵体内压（ICP）测量是国际公认的评估动物勃起功能的方法，然而，该过程具有侵入性、破坏性且不可重复，给整个治疗期间监测勃起功能的变化带来了巨大的挑战。验证基于红外线热成像技术的系统是否可以很好地替代ICP来评估大鼠的勃起功能。采用一种基于热图像的新型方法，红外线热成像技术（IRT）来监测勃起功能障碍（ED）大鼠的勃起功能。为了检测这项新技术的敏感性和特异性，建立了4种ED大鼠模型（糖尿病、神经损伤、血管损伤和老年ED模型）并进行ICP和IRT测试。进行了统计比较，以测试这种检测和动态监测勃起功能的新方法的有效性。从ICP和IRT获得的数据曲线来看，IRT表现出与ICP类似的趋势（包括峰值、爬升速度）。 IRT被认为是监测所有ED大鼠模型勃起功能实时变化的精确方法。 IRT在DMED、老年ED、血管损伤ED、神经损伤ED和总ED大鼠模型中检测到的峰值温度AUC分别为0.9811、0.9836、0.9893、0.9989和0.9882。同时，升温率的AUC分别为0.6486、0.8357、0.9184、0.8675和0.8168。而且，这是动态监测同一只大鼠不同时间点（药物干预前后）勃起功能的无创过程。数据显示，在糖尿病 ED (DMED) 大鼠模型中，即使仅治疗 2 周，他达拉非也能通过 IRT 方法获得实时恢复。建立了一种新的无创监测大鼠 ED 模型勃起功能的方法，可以替代或补充 ICP 测试。刘S，赵Z，王Z等。建立基于热成像技术（IRT）的系统来评估大鼠勃起功能。性医学 2022；10：100475。
Measurement of intra-cavernous pressure (ICP) is an internationally recognized method to evaluate erectile function of animals, however, this process is invasive, destructive, and cannot be repeated, leading to a daunting challenge for monitoring the changes in erectile function throughout the whole treatment duration. To verify whether infrared ray thermography technology based system could be a good substitution of ICP for evaluating rat erectile function. A novel thermal image-based method, infrared ray thermography technology (IRT) was employed to monitor erectile function in erectile dysfunction (ED) rats. To detect the sensitivity and specificity of this new technology, 4 ED rat models (Diabetic, nerve-injury, vascular-injury and aged ED models) were established and subjected to both ICP and IRT test. Statistical comparisons were done to test the effectiveness of this new way for detecting and dynamically monitoring erectile function. Based on the data curves obtained from ICP and IRT, the IRT showed a similar trend (including peak value, climbing speed) as that of ICP. IRT is considered as a precise way to monitor the real-time changes of erectile function in all ED rat models. The AUC of peak temperature detected by IRT in DMED, aged ED, vascular-injury ED, the nerve-injury ED and total ED rat models were 0.9811,0.9836,0.9893,0.9989 and 0.9882, respectively. Meanwhile, the AUC of temperature climbing rate were 0.6486,0.8357,0.9184,0.8675and 0.8168.Also,it is a non-invasive process of dynamically monitoring erectile function of a same rat at different time points (before and after drug intervention). The data showed that the real-time recovery by tadalafil was obtained by IRT methods even after treatment for only 2 weeks in the diabetic ED (DMED) rat model. A novel noninvasive method for monitoring erectile function in rat ED models was established, and can replace or supplement ICP test. Liu S, Zhao Z, Wang Z et al. Establishing a Thermal Imaging Technology (IRT) Based System for Evaluating Rat Erectile Function. Sex Med 2022;10:100475.
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DOI：
10.1016/j.bbrc.2018.10.036
发表时间：
2018-12-09
影响因子：
3.1
作者：
Hu, Liang-Liang;Zhang, Ke-Qin;Fu, Qiang
通讯作者：
Fu, Qiang
影响因子：
1.2
作者：
Hox, Morten;Mann-Gow, Travis;Zvara, Peter
通讯作者：
Zvara, Peter
影响因子：
4.5
作者：
Choo, S. H.;Sung, H. H.;Lee, S. W.
通讯作者：
Lee, S. W.
人尿干细胞移植通过促进糖尿病勃起功能障碍大鼠海绵体内皮细胞自噬改善勃起功能和海绵体内皮功能
影响因子：
4.3
作者：
Zhang, Chi;Luo, Daosheng;Liu, Guihua
通讯作者：
Liu, Guihua
影响因子：
4.6
作者：
Dong F;Tao C;Wu J;Su Y;Wang Y;Wang Y;Guo C;Lyu P
通讯作者：
Lyu P