Parental Obesity: Intergenerational Programming and Consequences
Parental Obesity: Intergenerational Programming and Consequences
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父母肥胖：代际规划及其后果
DOI：
10.1007/978-1-4939-6386-7_12
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Bruce K
中科院分区：
文献类型：
--
作者：
Bruce K
非酒精性脂肪性肝病（NAFLD）是目前全球慢性肝病最常见的原因，存在于三分之一的普通人群和大多数肥胖和2型糖尿病患者中。这种疾病的不太严重的形式是相对常见的，可以是良性的。然而，在某些个体中，该疾病可进展为更严重的非酒精性脂肪性肝炎（NASH），导致健康状况不佳、预后不良和显著的医疗保健负担。近年来，有一项主要的研究工作集中在确定促进NALFD疾病进展的因素上，因此，我们对营养与调节肝脏脂质稳态的分子机制之间相互作用的理解有了重大进展。尽管如此，母体饮食改变这些基本代谢途径的能力，从而引发成人肝脏中严重脂肪肝疾病的发展，已被证明是这项研究中最引人注目的发现之一。由于近年来母亲饮食的谨慎性已经动摇，这可以解释为什么NAFLD-曾经通常与老年人相关-现在在年轻人，儿童和青少年中越来越常见。在接下来的章节中，我们的目的是审查目前的假设，围绕NAFLD的发展启动的基础机制。我们还将探讨这些新的见解如何促进有前途的新的药理学和营养干预策略的出现。
Nonalcoholic fatty liver disease (NAFLD) is currently the most common cause of chronic liver disease worldwide and is present in a third of the general population and the majority of individuals with obesity and type 2 diabetes. The less severe form of the disease is relatively common and can be somewhat benign. However, in certain individuals, the disease can progress to the more severe nonalcoholic steatohepatitis (NASH), resulting in a poor health, a poor prognosis, and a significant healthcare burden. In recent years, there has been a major research effort focused on identifying the factors that promote NALFD disease progression, and as a result there has been a significant advancement in our understanding of the interaction between nutrition and the molecular mechanisms that regulate hepatic lipid homeostasis. Nonetheless, the capacity of the maternal diet to alter these fundamental metabolic pathways and thus prime the development of severe fatty liver disease in the adult liver has proved to be one of the most striking findings from this body of research. Since the prudence of the maternal diet has wavered in recent years, this may explain why NAFLD—once commonly associated with older individuals—is now increasingly common in young adults, children, and adolescents. In the following chapter, we aim to review the current hypothesis surrounding the mechanisms that underlie the developmental priming of NAFLD. We will also explore how these novel insights have facilitated the emergence of promising new pharmacological and nutritional intervention strategies.
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DOI：
10.1016/j.ejogrb.2015.06.031
发表时间：
2015-10
期刊：
European journal of obstetrics, gynecology, and reproductive biology
影响因子：
--
作者：
Bahadoer S;Gaillard R;Felix JF;Raat H;Renders CM;Hofman A;Steegers EA;Jaddoe VW
通讯作者：
Jaddoe VW
影响因子：
6.7
作者：
Colaci, Daniela S.;Afeiche, Myriam;Gaskins, Audrey J.;Wright, Diane L.;Toth, Thomas L.;Tanrikut, Cigdem;Hauser, Russ;Chavarro, Jorge E.
通讯作者：
Chavarro, Jorge E.
精液蛋白质组学
影响因子：
8.2
作者：
Benjamin Solomon;M. Duncan
通讯作者：
M. Duncan
快速报告：怀孕前的饮食干预逆转了肥胖大鼠雄性后代的代谢程序
DOI：
--
发表时间：
2010
期刊：
Journal of Physiology
影响因子：
--
作者：
E. Zambrano;P. Martínez‐Samayoa;G. L. Rodríguez;P. Nathanielsz
通讯作者：
P. Nathanielsz
肥胖手术导致产妇体重大幅减轻，可防止肥胖传染给儿童，并对其进行了 2 至 18 年的随访。
影响因子：
8
作者：
J. Kral;S. Biron;S. Simard;F. Hould;S. Lebel;S. Marceau;P. Marceau
通讯作者：
P. Marceau