Referral Patterns of Patients with Limbal Stem Cell Deficiency to a Specialized Tertiary Center in the United Kingdom.
Referral Patterns of Patients with Limbal Stem Cell Deficiency to a Specialized Tertiary Center in the United Kingdom.
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DOI：
10.1007/s40123-021-00349-y
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发表时间：
2021-09
影响因子：
3.3
通讯作者：
Figueiredo FC
中科院分区：
文献类型：
--
作者：
Cartes C;Lako M;Figueiredo FC
角膜缘干细胞缺乏症（LSCD）是一种潜在的致盲性疾病;因此，转诊到专科服务变得越来越普遍。我们的目的是调查转诊模式和相关细节。我们对2011年至2018年期间被转介到我们服务的100名连续LSCD患者进行了审计。记录患者的人口统计学资料、地理位置、LSCD的原因、共存的眼部疾病、最佳矫正视力（BCVA）和LSCD的程度。进一步分析了以下两个亚组：（1）烧伤和（2）其他原因的LSCD。在100例患者（138只眼）中，70%为男性，平均年龄为45岁（SD 19）。62%的病例为单侧LSCD。最常见的眼部合并症是青光眼，21例（33只眼）。烧伤是最常见的转诊原因（61%）。受累眼的平均BCVA为1.22（SD 0.8）LogMAR，75只眼（54%）存在总LSCD。烧伤组和其他原因组之间的年龄、性别和眼睛受累差异具有统计学意义，平均年龄分别为39岁（标准差17）和53岁（标准差19）（p < 0.001）; 85%为男性，48.7%（p = 0.001）; 82%为单侧，31%（p < 0.001）。LSCD在男性中更常见，通常是单侧的。总体而言，LSCD的主要原因是烧伤。烧伤组与其他原因导致的LSCD组在年龄、性别和单方面参与方面存在显着差异，这可能有助于指导管理决策。
Limbal stem cell deficiency (LSCD) is a potentially blinding disease; hence, referral to a specialist service is becoming increasingly common. Our aim was to investigate the referral patterns and associated details. We conducted an audit of 100 consecutive patients with LSCD who were referred to our service from 2011 to 2018. Patient demographics, geographical location, cause of LSCD, coexisting ocular diseases, best corrected visual acuity (BCVA), and extent of LSCD were recorded. The following two subgroups were further analyzed: (1) burns and (2) other causes of LSCD. Out of the 100 patients (138 eyes), 70% were male, with a mean age of 45 years (SD 19). LSCD was unilateral in 62% of the cases. The most common ocular comorbidity was glaucoma, in 21 patients (33 eyes). Burns were the most frequent cause of referral (61%). The mean BCVA of the involved eye was 1.22 (SD 0.8) LogMAR, and total LSCD was present in 75 eyes (54%). There were statistically significant age, gender and eye-involved differences between the burns group and other causes group, mean 39 (SD 17) and 53 (SD 19) years (p < 0.001); 85% were men versus 48.7%, (p = 0.001); and 82% were unilateral versus 31% (p < 0.001), respectively. LSCD was more common in men and usually unilateral. Overall, the main cause of LSCD was burns. There were significant differences between the burns group and other causes of LSCD group in terms of age, gender and unilateral involvement that may help to guide management decisions.
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