Intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation.
Intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency biphasic stimulation.
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DOI：
10.1088/1741-2552/ac81ef
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发表时间：
2022-07-28
影响因子：
4
通讯作者：
Tai, Changfeng
中科院分区：
文献类型：
--
作者：
Zhong, Yihua;Zhang, Xu;Beckel, Jonathan;de Groat, William C.;Tai, Changfeng
采用一种新的轴突传导模型，分析了高频双相刺激（HFBS）引起的轴突传导阻滞中细胞内钠离子浓度与膜电位振荡的相互作用。该模型包括细胞内和细胞外的钠和钾浓度和离子泵。首先，施加HFBS（1kHz，5.4mA）足够长的持续时间（59.4秒）以在终止刺激后产生轴突传导阻滞，即，刺激后阻滞然后，HFBS的强度降低到较低水平4秒，以确定轴突传导阻滞是否可以维持。当HFBS强度从0 mA增加到4.1 mA时，阻滞持续时间从1363 ms缩短到5 ms。如果降低的强度高于4.2 mA，则在整个测试周期（4000 ms）内保持阻滞。在低强度（<4.2mA）下，膜电位振荡破坏了由细胞内钠浓度增加引起的刺激后阻滞，而在高强度（> 4.2mA）下，膜电位振荡足够强以维持阻滞并进一步增加细胞内钠浓度。这项研究表明，有可能开发一种新的神经阻滞方法，以减少HFBS强度，这可以延长电池寿命的植入式神经刺激器在临床应用中，以阻止周围起源的疼痛。
A new axonal conduction model was used to analyze the interaction between intracellular sodium concentration and membrane potential oscillation in axonal conduction block induced by high-frequency (kHz) biphasic stimulation (HFBS). The model includes intracellular and extracellular sodium and potassium concentrations and ion pumps. First, the HFBS (1 kHz, 5.4 mA) was applied for a duration (59.4 seconds) long enough to produce an axonal conduction block after terminating the stimulation, i.e., a post-stimulation block. Then, the intensity of HFBS was reduced to a lower level for 4 seconds to determine if the axonal conduction block could be maintained. The block duration was shortened from 1363 ms to 5 ms as the reduced HFBS intensity was increased from 0 mA to 4.1 mA. The block was maintained for the entire tested period (4000 ms) if the reduced intensity was above 4.2 mA. At the low intensity (<4.2 mA) the membrane potential oscillation disrupted the post-stimulation block caused by the increased intracellular sodium concentration, while at the high intensity (>4.2 mA) the membrane potential oscillation was strong enough to maintain the block and further increased the intracellular sodium concentration. This study indicates a possibility to develop a new nerve block method to reduce the HFBS intensity, which can extend the battery life for an implantable nerve stimulator in clinical applications to block pain of peripheral origin.
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DOI：
10.1111/ner.13241
发表时间：
2021-08
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Shapiro K;Guo W;Armann K;Pace N;Shen B;Wang J;Beckel J;de Groat W;Tai C
通讯作者：
Tai C
影响因子：
2.8
作者：
Soin, Amol;Shah, Nemath Syed;Fang, Zi-Ping
通讯作者：
Fang, Zi-Ping
DOI：
10.1111/ner.13501
发表时间：
2023-04
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
--
作者：
Zhong Y;Wang J;Beckel J;de Groat WC;Tai C
通讯作者：
Tai C
影响因子：
3.2
作者：
Yang, Guangning;Xiao, Zhiying;Wang, Jicheng;Shen, Bing;Roppolo, James R.;de Groat, William C.;Tai, Changfeng
通讯作者：
Tai, Changfeng
影响因子：
9.8
作者：
WHITWAM, JG;KIDD, C
通讯作者：
KIDD, C