Transcriptional Regulation of Pattern-Triggered Immunity in Plants.

Transcriptional Regulation of Pattern-Triggered Immunity in Plants.
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DOI:
10.1016/j.chom.2016.04.011
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发表时间:
2016-05-11
影响因子:
30.3
通讯作者:
He P
He P
中科院分区:
医学1区
文献类型:
--
作者:
Li B;Meng X;Shan L;He P

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细胞表面模式识别受体(PRRs)对微生物相关分子模式(MAMPs)的感知可诱导快速、稳健和选择性的转录重编程,这是启动植物有效模式触发免疫(PTI)的关键。从PRR复合物到核转录机器的信号中继通过细胞内激酶级联快速激活初级免疫应答基因。基因特异性转录因子和一般转录机制的协同作用有助于免疫基因激活的选择性。此外,PRR复合物和信号成分通常在MAMP感知后转录上调,以确保PTI输出的稳健性和可持续性。在这篇综述中,我们讨论了最近的进展,破译信号通路和调控机制,协调导致及时和准确的MAMP诱导的基因表达在植物中。
Perception of microbe-associated molecular patterns (MAMPs) by cell surface-resident pattern recognition receptors (PRRs) induces rapid, robust and selective transcriptional reprogramming, which is central for launching effective pattern-triggered immunity (PTI) in plants. Signal relay from PRR complexes to the nuclear transcriptional machinery via intracellular kinase cascades rapidly activates primary immune response genes. The coordinated action of gene-specific transcription factors and the general transcriptional machinery contributes to the selectivity of immune gene activation. In addition, PRR complexes and signaling components are often transcriptionally up-regulated upon MAMP perception to ensure the robustness and sustainability of PTI outputs. In this review, we discuss recent advances in deciphering the signaling pathways and regulatory mechanisms that coordinately lead to timely and accurate MAMP-induced gene expression in plants.
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