Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism.
Biological and Pharmacological Potential of Xylitol: A Molecular Insight of Unique Metabolism.
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DOI：
10.3390/foods9111592
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发表时间：
2020-11-02
期刊：
影响因子：
--
通讯作者：
Saurav K
中科院分区：
文献类型：
--
作者：
Ahuja V;Macho M;Ewe D;Singh M;Saha S;Saurav K
木糖醇是一种白色结晶、无定形糖醇和低热量甜味剂。木糖醇可预防牙齿和骨骼的脱矿、中耳炎感染、呼吸道感染、炎症和癌症进展。木糖醇代谢中产生的NADPH有助于治疗葡萄糖-6-磷酸缺乏相关的溶血性贫血。此外，由于其独特的代谢，它对血糖和血浆胰岛素水平的影响可以忽略不计。其在制药、化妆品、食品和聚合物行业的广泛应用推动了其市场增长，使其成为12大生物产品之一。近年来，木糖醇由于其高渗透性和无毒的性质也被用作药物载体。然而，满足快速增长的木糖醇市场需求成为一个挑战。木糖醇存在于水果和蔬菜中，但浓度很低，不足以满足消费者的需求。随着时间的推移，其他方法，包括化学催化，微生物和酶的生物转化，也被开发用于其大规模生产。然而，大规模生产仍然受到高生产成本的困扰。在这篇综述中，我们总结了一些替代方法和最近的进展，显着提高产量和降低生产成本。
Xylitol is a white crystalline, amorphous sugar alcohol and low-calorie sweetener. Xylitol prevents demineralization of teeth and bones, otitis media infection, respiratory tract infections, inflammation and cancer progression. NADPH generated in xylitol metabolism aid in the treatment of glucose-6-phosphate deficiency-associated hemolytic anemia. Moreover, it has a negligible effect on blood glucose and plasma insulin levels due to its unique metabolism. Its diverse applications in pharmaceuticals, cosmetics, food and polymer industries fueled its market growth and made it one of the top 12 bio-products. Recently, xylitol has also been used as a drug carrier due to its high permeability and non-toxic nature. However, it become a challenge to fulfil the rapidly increasing market demand of xylitol. Xylitol is present in fruit and vegetables, but at very low concentrations, which is not adequate to satisfy the consumer demand. With the passage of time, other methods including chemical catalysis, microbial and enzymatic biotransformation, have also been developed for its large-scale production. Nevertheless, large scale production still suffers from high cost of production. In this review, we summarize some alternative approaches and recent advancements that significantly improve the yield and lower the cost of production.
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影响因子：
2.4
作者：
Amo K;Arai H;Uebanso T;Fukaya M;Koganei M;Sasaki H;Yamamoto H;Taketani Y;Takeda E
通讯作者：
Takeda E
DOI：
10.3390/ijerph16050832
发表时间：
2019-03-01
影响因子：
--
作者：
Bhuvaneshwari, S.;Hettiarachchi, Hiroshan;Meegoda, Jay N.
通讯作者：
Meegoda, Jay N.
影响因子：
6.4
作者：
Cheng H;Wang B;Lv J;Jiang M;Lin S;Deng Z
通讯作者：
Deng Z
影响因子：
3.7
作者：
Atzmueller, Denise;Ullmann, Nadine;Zwirzitz, Alexander
通讯作者：
Zwirzitz, Alexander
DOI：
10.1590/0104-6632.20190361s20170643
发表时间：
2019-03-01
影响因子：
1.2
作者：
Camargo, Danille;Sydney, Eduardo B.;Sene, Luciane
通讯作者：
Sene, Luciane