Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.
Association Analysis of IL10, TNF-α, and IL23R-IL12RB2 SNPs with Behçet's Disease Risk in Western Algeria.
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DOI：
10.3389/fimmu.2013.00342
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发表时间：
2013
影响因子：
7.3
通讯作者：
Barat-Houari M
中科院分区：
文献类型：
--
作者：
Khaib Dit Naib O;Aribi M;Idder A;Chiali A;Sairi H;Touitou I;Lefranc G;Barat-Houari M
目的：我们在阿尔及利亚西部首次开展了白细胞介素 (IL)-10、肿瘤坏死因子 α (TNF-α) 和 IL23R-IL12RB2 区域单核苷酸多态性 (SNP) 与白塞病 (BD) 关联的研究。方法：通过直接测序对来自阿尔及利亚西部地区的 51 名 BD 患者和 96 名无关对照者进行基因分型，其中包括 2 个来自 IL10 启动子的 SNP [c.-819T > C (rs1800871)、c.-592A > C (rs1800872)]、6 个来自 TNF-α 的 SNP启动子 [c.-1211T > C (rs1799964)、c.-1043C > A (rs1800630)、c.-1037C > T (rs1799724)、c.-556G > A (rs1800750)、 c.-488G > A (rs1800629) 和 c.-418G > A (rs361525)]，以及来自 IL23R-IL12RB2 区域的 3 个 SNP [g.67747415A > C (rs12119179)， g.67740092G > A（rs11209032）和g.67760140T > C（rs924080）]。结果：次要等位基因 c.-819T 和 c.-592A 与 BD 显着相关[比值比 (OR) = 2.18； 95% 置信区间 (CI) 1.28–3.73, p = 0.003]；然而，TNF-α 启动子 SNP 或 IL23R-IL12RB2 区域与疾病风险之间的关联较弱。结论：与 TNF-α 和 IL23R-IL12RB2 区域 SNP 不同，这两个 IL10 SNP 与 BD 密切相关。 -819T和-592A等位基因以及-819TT、-819CT、-592AA和-592CA基因型似乎与阿尔及利亚西部人群患BD的风险高度相关。
Objective: We have conducted the first study of the association of interleukin (IL)-10, tumor necrosis factor alpha (TNF-α), and IL23R-IL12RB2 region single nucleotide polymorphisms (SNPs) with Behçet’s disease (BD) in Western Algeria. Methods: A total of 51 BD patients and 96 unrelated controls from West region of Algeria were genotyped by direct sequencing for 11 SNPs including 2 SNPs from the IL10 promoter [c.-819T > C (rs1800871), c.-592A > C (rs1800872)], 6 SNPs from the TNF-α promoter [c.-1211T > C (rs1799964), c.-1043C > A (rs1800630), c.-1037C > T (rs1799724), c.-556G > A (rs1800750), c.-488G > A (rs1800629), and c.-418G > A (rs361525)], and 3 SNPs from the IL23R-IL12RB2 region [g.67747415A > C (rs12119179), g.67740092G > A (rs11209032), and g.67760140T > C (rs924080)]. Results: The minor alleles c.-819T and c.-592A were significantly associated with BD [odds ratio (OR) = 2.18; 95% confidence interval (CI) 1.28–3.73, p = 0.003]; whereas, there was weaker association between TNF-α promoter SNPs or IL23R-IL12RB2 region and disease risk. Conclusion: Unlike the TNF-α and the IL23R-IL12RB2 region SNPs, the two IL10 SNPs were strongly associated with BD. The -819T, and -592A alleles and the -819TT, -819CT, and -592AA and -592CA genotypes seem to be highly involved in the risk of developing of BD in the population of Western Algeria.
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影响因子：
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作者：
Higuchi, T;Seki, N;Itoh, K
通讯作者：
Itoh, K
影响因子：
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作者：
Jang, Won-Cheoul;Nam, Yun-Hyoung;Kim, Seong-Kyu
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Kim, Seong-Kyu
影响因子：
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作者：
de Menthon, Mathilde;LaValley, Michael P.;Maldini, Carla;Guillevin, Loic;Mahr, Alfred
通讯作者：
Mahr, Alfred
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Cheng G
影响因子：
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Esin, S;Gul, A;Wigzell, H
通讯作者：
Wigzell, H