HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.
HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.
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DOI：
10.1002/art.24642
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发表时间：
2009-10-15
影响因子：
4.7
通讯作者：
Mahr, Alfred
中科院分区：
文献类型：
--
作者：
de Menthon, Mathilde;LaValley, Michael P.;Maldini, Carla;Guillevin, Loic;Mahr, Alfred
通过荟萃分析量化 HLA-B5 或 HLA-B51 (HLA-B51/B5) 等位基因对患白塞氏病 (BD) 风险的遗传影响，并寻找潜在的效应调节剂。使用 PubMed Medline 数据库和手动检索文献来确定相关研究。使用随机效应模型计算汇总比值比 (OR) 和 95% 置信区间 (95% CI)。进行了亚组荟萃分析和荟萃回归分析，以调查所选研究水平参数对汇总 OR 的影响。使用 I2 统计量评估异质性。汇总结果用于计算 BD 与 HLA-B51/B5 相关的人群归因风险 (PAR)。共有来自 78 项独立研究（1975-2007 年发表）的 4,800 名 BD 患者和 16,289 名对照者被选中。与非携带者相比，HLA–B51/B5 等位基因携带者患 BD 的汇总 OR 为 5.78 (95% CI 5.00–6.67)，研究间异质性中等 (I2 = 61%)。该亚组按地理位置（东亚、中东/北非、南欧、北欧/东欧）对分层研究进行分析，得出一致的 OR 范围 (5.31–7.20)，I2 范围为 52–70%。单变量随机效应元回归表明男性 BD 病例的百分比 (P = 0.008) 是异质性的一个来源。不同地理区域内的 PAR 估计为 32-52%。 BD 和 HLA-B51/B5 之间的关联强度及其在不同种族人群中的一致性，进一步支持该等位基因是 BD 的主要因果风险决定因素。性别差异支持该等位基因与 BD 特征的相互作用。
To quantify by meta-analysis the genetic effect of the HLA–B5 or HLA–B51 (HLA–B51/B5) allele on the risk of developing Behçet’s disease (BD) and to look for potential effect modifiers. Relevant studies were identified using the PubMed Medline database and manual searches of the literature. Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated by using the random-effects model. Subgroup meta-analyses and meta-regression analyses were undertaken to investigate the effects of selected study-level parameters on the pooled OR. Heterogeneity was assessed using the I2 statistic. Pooled results were used to calculate population-attributable risks (PAR) for BD in relationship to HLA–B51/B5. A total of 4,800 patients with BD and 16,289 controls from 78 independent studies (published 1975–2007) were selected. The pooled OR of HLA–B51/B5 allele carriers to develop BD compared with noncarriers was 5.78 (95% CI 5.00–6.67), with moderate between-study heterogeneity (I2 = 61%). The subgroup analyses stratifying studies by geographic locations (Eastern Asia, Middle East/North Africa, Southern Europe, Northern/Eastern Europe) yielded consistent OR ranges (5.31–7.20), with I2 ranges of 52–70%. Univariate random-effects meta-regression indicated the percentage of male BD cases (P = 0.008) as a source of heterogeneity. The PAR within the various geographic areas were estimated at 32–52%. The strength of the association between BD and HLA–B51/B5, and its consistency across populations of various ethnicities, lends further support to this allele being a primary and causal risk determinant for BD. Variations according to sex support an interaction of this allele with BD characteristics.
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影响因子：
2.7
作者：
Du, Ke-Ming;Ji, Yun;Zhao, Tong-Mao
通讯作者：
Zhao, Tong-Mao
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
2.7
作者：
Choukri, F;Chakib, A;Caillat-Zucman, S
通讯作者：
Caillat-Zucman, S
影响因子：
3.4
作者：
AZIZLERLI, G;AKSUNGUR, VL;OVUL, C
通讯作者：
OVUL, C
影响因子：
1.9
作者：
BEGG, CB;MAZUMDAR, M
通讯作者：
MAZUMDAR, M