Cerebral perfusion differences in women currently with and recovered from anorexia nervosa.
Cerebral perfusion differences in women currently with and recovered from anorexia nervosa.
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DOI：
10.1016/j.pscychresns.2015.02.008
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发表时间：
2015-05-30
影响因子：
11.3
通讯作者：
McAdams CJ
中科院分区：
文献类型：
--
作者：
Sheng M;Lu H;Liu P;Thomas BP;McAdams CJ
神经性厌食症是一种严重的精神疾病，其特征是限制进食，追求苗条，改变对身体形状和大小的感知。神经性厌食症的神经影像学检查揭示了大脑的形态和功能改变。更好地了解神经性厌食症的生理变化可以提供与治疗和结果相关的大脑特异性健康标志物。在这项研究中，我们应用了几种先进的磁共振成像（MRI）技术，以量化区域和全球脑血流量（CBF）在25名健康女性（HC），23名患者目前厌食症（AN-C）和19名患者在长期体重恢复厌食症（AN-WR）。具体而言，CBF测量与伪连续动脉自旋标记（pCASL）MRI，然后验证了不同的技术，相位对比（PC）MRI。通过自旋标记（TRUST）MRI下的T2弛豫测定静脉T2值，并用于证实CBF结果。这些新技术在标准3 T MRI扫描仪上实现，没有任何外源性示踪剂，总扫描时间小于10 min。体素比较显示，AN-WR组双侧颞叶和额叶的CBF低于AN-C组。与HC组相比，AN-C组的右侧颞叶CBF也较高。与AN-C组相比，AN-WR组的全脑平均CBF显著降低，与PC-MRI结果一致。AN-WR组的静脉T2值低于AN-C组，与CBF结果一致。回顾以往的工作检查脑血流神经性厌食症包括在讨论中。这项研究确定了神经性厌食症大脑生理改变的几个差异，并发现了与疾病当前状态相关的具体差异。
Anorexia nervosa is a serious psychiatric disorder characterized by restricted eating, a pursuit of thinness, and altered perceptions of body shape and size. Neuroimaging in anorexia nervosa has revealed morphological and functional alterations in the brain. A better understanding of physiological changes in anorexia nervosa could provide a brain-specific health marker relevant to treatment and outcomes. In this study, we applied several advanced magnetic resonance imaging (MRI) techniques to quantify regional and global cerebral blood flow (CBF) in 25 healthy women (HC), 23 patients currently with anorexia (AN-C) and 19 patients in long-term weight recovery following anorexia (AN-WR). Specifically, CBF was measured with pseudo-continuous arterial spin labeling (pCASL) MRI and then verified by a different technique, phase contrast (PC) MRI. Venous T2 values were determined by T2 relaxation under spin tagging (TRUST) MRI, and were used to corroborate the CBF results. These novel techniques were implemented on a standard 3T MRI scanner without any exogenous tracers, and the total scan duration was less than 10 min. Voxel-wise comparison revealed that the AN-WR group showed lower CBF in bilateral temporal and frontal lobes than the AN-C group. Compared with the HC group, the AN-C group also showed higher CBF in the right temporal lobe. Whole-brain-averaged CBF was significantly decreased in the AN-WR group compared with the AN-C group, consistent with the PC-MRI results. Venous T2 values were lower in the AN-WR group than in the AN-C group, consistent with the CBF results. A review of prior work examining CBF in anorexia nervosa is included in the discussion. This study identifies several differences in the cerebral physiological alterations in anorexia nervosa, and finds specific differences relevant to the current state of the disorder.
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影响因子：
6.9
作者：
Hoek, Hans Wijbrand
通讯作者：
Hoek, Hans Wijbrand
影响因子：
6.3
作者：
Ge, Yulin;Zhang, Zhongwei;Grossman, Robert I.
通讯作者：
Grossman, Robert I.
影响因子：
2.3
作者：
Clark, Camellia P.;Brown, Gregory G.;Gillin, J. Christian
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Gillin, J. Christian
影响因子：
3.3
作者：
DETRE, JA;LEIGH, JS;KORETSKY, AP
通讯作者：
KORETSKY, AP
影响因子：
14.5
作者：
BROWN, MM;WADE, JPH;MARSHALL, J
通讯作者：
MARSHALL, J