Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation.
Conduction block in myelinated axons induced by high-frequency (kHz) non-symmetric biphasic stimulation.
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DOI：
10.3389/fncom.2015.00086
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发表时间：
2015
影响因子：
3.2
通讯作者：
Tai C
中科院分区：
文献类型：
--
作者：
Zhao S;Yang G;Wang J;Roppolo JR;de Groat WC;Tai C
This study used the Frankenhaeuser–Huxley axonal model to analyze the effects of non-symmetric waveforms on conduction block of myelinated axons induced by high-frequency (10–300 kHz) biphasic electrical stimulation. The results predict a monotonic relationship between block threshold and stimulation frequency for symmetric waveform and a non-monotonic relationship for non-symmetric waveforms. The symmetric waveform causes conduction block by constantly activating both sodium and potassium channels at frequencies of 20–300 kHz, while the non-symmetric waveforms share the same blocking mechanism from 20 kHz up to the peak threshold frequency. At the frequencies above the peak threshold frequency the non-symmetric waveforms block axonal conduction by either hyperpolarizing the membrane (if the positive pulse is longer) or depolarizing the membrane (if the negative pulse is longer). This simulation study further increases our understanding of conduction block in myelinated axons induced by high-frequency biphasic electrical stimulation, and can guide future animal experiments as well as optimize stimulation parameters that might be used for electrically induced nerve block in clinical applications.
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影响因子：
4
作者：
Ackermann DM;Bhadra N;Gerges M;Thomas PJ
通讯作者：
Thomas PJ
影响因子：
3.4
作者：
Bhadra, N;Kilgore, KL
通讯作者：
Kilgore, KL
DOI：
10.1109/tnsre.2011.2163082
发表时间：
2011-10
期刊：
IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
影响因子：
--
作者：
Joseph L;Butera RJ
通讯作者：
Butera RJ
影响因子：
4.6
作者：
ROTH, BJ
通讯作者：
ROTH, BJ
影响因子：
5.5
作者：
FRANKENHAEUSER, B;HUXLEY, AF
通讯作者：
HUXLEY, AF