Individual differences in the conditioned and unconditioned rat 50-kHz ultrasonic vocalizations elicited by repeated amphetamine exposure.
Individual differences in the conditioned and unconditioned rat 50-kHz ultrasonic vocalizations elicited by repeated amphetamine exposure.
复制标题
反复暴露的条件和无条件的大鼠50-kHz超声发声的个体差异。
DOI：
10.1007/s00213-013-3130-9
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发表时间：
2013-10
影响因子：
3.4
通讯作者：
Schallert, Timothy
中科院分区：
文献类型：
--
作者：
Ahrens, Allison M.;Nobile, Cameron W.;Page, Lindsay E.;Maier, Esther Y.;Duvauchelle, Christine L.;Schallert, Timothy
成年大鼠在有食欲的情况下经常产生50千赫的超声波（usv），特别是频率调制的品种。一些人认为，这些叫声反映了积极的情感状态，以及安非他明和可卡因等药物的强化作用。本研究的目的是确定安非他明引起的50 khz非条件性usv的数量是否能预测药物条件性动机的发展和/或大小。在三个实验中，我们记录了每次注射一次1 mg/kg安非他明（静脉注射或静脉注射）前后的usv。根据第一次注射安非他明引起的50 khz usv数量的个体差异，将大鼠分为“高叫唤者”和“低叫唤者”。我们研究了在特定情境中反复配对安非他明后，高呼叫者和低呼叫者的条件性食欲行为和条件性位置偏好（CPP）。我们还研究了安非他明诱导的呼叫是否受到不熟悉（实验室）和熟悉（家笼）环境的影响。在不熟悉的环境中，高呼叫者始终比低呼叫者产生更多安非他明诱导的50 khz usv。与低呼叫者相比，高呼叫者表现出更高的安非他明CPP，并在安非他明预期期间增强了条件50-kHz usv和运动活动。当在测试室中使用安非他明时，个体差异是稳定的，但当在家庭笼子中使用安非他明时，低呼叫者显示出与高呼叫者相匹配的50 khz呼叫增加。这些发现表明，药物诱导usv的个体差异可以揭示与药物相关的食欲动机有关的环境敏感特征。
Adult rats often produce 50-kHz ultrasonic vocalizations (USVs), particularly the frequency-modulated varieties, in appetitive situations. These calls are thought by some to reflect positive affective states and the reinforcing value of drugs such as amphetamine and cocaine. The objective of this study was to determine whether the number of unconditioned 50-kHz USVs elicited by amphetamine predicts the development and/or magnitude of drug-conditioned motivation. In three experiments, we recorded USVs before and after injections of 1 mg/kg amphetamine (i.v. or i.p.) administered once per session. Rats were categorized as “high callers” or “low callers” according to individual differences in the number of 50-kHz USVs elicited by their first amphetamine injection. We examined the conditioned appetitive behavior and conditioned place preference (CPP) that emerged in high and low callers after repeated pairings of amphetamine with specific contexts. We also examined whether amphetamine-induced calling was affected by treatment within an unfamiliar (test chamber) versus familiar (home cage) context. Within an unfamiliar environment, the high callers consistently produced more amphetamine-induced 50-kHz USVs than the low callers. Compared to the low callers, high callers showed significantly greater amphetamine CPP as well as enhanced conditioned 50-kHz USVs and locomotor activity during anticipation of amphetamine. Individual differences were stable when amphetamine was administered in test chambers, but when it was administered in home cages, low callers showed an increase in 50-kHz calling that matched the high callers. These findings suggest that individual differences in drug-induced USVs can reveal environment-sensitive traits involved in drug-related appetitive motivation.
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影响因子：
1.9
作者：
Burgdorf, J;Knutson, B;Ikemoto, S
通讯作者：
Ikemoto, S
影响因子：
4.7
作者：
Browning JR;Browning DA;Maxwell AO;Dong Y;Jansen HT;Panksepp J;Sorg BA
通讯作者：
Sorg BA
影响因子：
10.6
作者：
Ferrario, CR;Gorny, G;Robinson, TE
通讯作者：
Robinson, TE
影响因子：
1.6
作者：
Flagel, Shelly B.;Robinson, Terry E.
通讯作者：
Robinson, Terry E.
影响因子：
1.4
作者：
Burgdorf, Jeffrey;Kroes, Roger A.;Panksepp, Jaak
通讯作者：
Panksepp, Jaak