A brief olfactory test for Alzheimer's disease.
A brief olfactory test for Alzheimer's disease.
复制标题
DOI：
10.1016/j.jns.2013.06.033
复制
发表时间：
2013-10-15
影响因子：
4.4
通讯作者：
Heilman, Kenneth M.
中科院分区：
文献类型：
--
作者：
Stamps, Jennifer J.;Bartoshuk, Linda M.;Heilman, Kenneth M.
关键词：
阿尔茨海默病（AD）的早期诊断可能有助于减少残疾，提高生活质量，并有助于临床试验。部分嗅觉皮层是AD病理的起始部位，并且AD患者的左半球比右半球更易变性。由于嗅上皮主要投射到同侧嗅皮层，AD患者可能表现出不对称的（左侧大于右侧）气味检测灵敏度降低。这项回顾性病例对照研究评估了一种可能有助于诊断AD的快速嗅觉测试。参与者可能AD（N=18），轻度认知障碍（MCI，N=24），其他原因的痴呆症（OD，N=26）和匹配的控制（OC，N=26）进行了测试，闭上眼睛，他们的能力检测气味，一次一个鼻孔。打开一个装有14克花生酱的容器，将其放在一个30厘米的尺子底部，在参与者呼气期间每次向上移动1厘米。在气味检测时，测量受试者的鼻孔和容器之间的距离。AD患者左侧鼻孔的平均气味检测距离（5.1 cm）显著小于其他组（F（3，90）= 22.28，p < 0.0001），而右侧鼻孔的平均气味检测距离（17.4 cm）则没有。AD患者的L R R气味检测差异（cm）的平均值、标准误和95%置信区间为−12.4 ±0.5（−15.0，−9.8）; MCI患者为−1.9 ±1.2（− 4.2，0.4）; OD患者为4.8 ±1.0（2.6，6.9）; OC患者为0.0 ±1.4（− 2.2，2.1）。这种非侵入性和廉价的左-右气味检测测试似乎是一个敏感和具体的测试可能的广告。
The early diagnosis of Alzheimer’s disease (AD) may help reduce disability, enhance quality of life, and aid clinical trials. Portions of olfactory cortex are the initial sites of AD pathology and patients with AD often have more degeneration of their left than right hemisphere. Since the olfactory epithelium projects mainly to the ipsilateral olfactory cortex, patients with AD may demonstrate an asymmetrical (left greater than right) decrement of odor detection sensitivity. This retrospective, case-control study assessed a quick olfactory test that may help diagnose AD. Participants with probable AD (N=18), mild cognitive impairment (MCI, N=24), other causes of dementia (OD, N=26) and matched controls (OC, N=26) were tested, with closed eyes, for their ability to detect an odor, one nostril at a time. A container of 14g of peanut butter was opened, held medially at the bottom of a 30 cm ruler, and moved up 1cm at a time during the participants’ exhale. Upon odor detection, the distance between the subject’s nostril and container was measured. The mean odor detection distance of AD patients’ left nostril (5.1 cm), and not their right (17.4 cm), was significantly less (F(3,90) = 22.28, p < 0.0001) than the other groups. The mean, standard error, and 95% Confidence Interval of the L R nostril odor detection difference (cm) for AD was −12.4 ±0.5, (−15.0, −9.8); for MCI was −1.9 ±1.2, (−4.2,0.4); for OD was 4.8 ±1.0, (2.6,6.9); and for OC was 0.0 ±1.4 (−2.2,2.1). This non-invasive and inexpensive left-right nostril odor detection test appears to be a sensitive and specific test for probable AD.
登录
查看更多内容
影响因子：
9.9
作者：
KOSS, E;WEIFFENBACH, JM;FRIEDLAND, RP
通讯作者：
FRIEDLAND, RP
DOI：
10.1080/01688638708405208
发表时间：
1987-12-01
影响因子：
2.2
作者：
MOBERG, PJ;PEARLSON, GD;FOLSTEIN, SE
通讯作者：
FOLSTEIN, SE
DOI：
10.1016/j.jalz.2011.03.005
发表时间：
2011-05
期刊：
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子：
--
作者：
McKhann GM;Knopman DS;Chertkow H;Hyman BT;Jack CR Jr;Kawas CH;Klunk WE;Koroshetz WJ;Manly JJ;Mayeux R;Mohs RC;Morris JC;Rossor MN;Scheltens P;Carrillo MC;Thies B;Weintraub S;Phelps CH
通讯作者：
Phelps CH
DOI：
10.1111/j.1749-6632.1998.tb10659.x
发表时间：
1998-01-01
期刊：
OLFACTION AND TASTE XII
影响因子：
--
作者：
Davidson, TM;Freed, C;Murphy, C
通讯作者：
Murphy, C
影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B