Context-dependent odor learning requires the anterior olfactory nucleus.
Context-dependent odor learning requires the anterior olfactory nucleus.
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DOI：
10.1037/bne0000371
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发表时间：
2020-08
影响因子：
1.9
通讯作者：
Linster C
中科院分区：
文献类型：
--
作者：
Levinson M;Kolenda JP;Alexandrou GJ;Escanilla O;Cleland TA;Smith DM;Linster C
学会将刺激发生的环境联系起来是动物学习的一个重要方面。我们提出，嗅觉刺激与其多感觉背景的关联是由腹侧海马网络（vHC）到前嗅核（AON）的投射介导的。使用上下文线索嗅觉辨别任务，大鼠被训练将两个嗅觉刺激与取决于视觉空间上下文的不同反应相关联。AON或vHC的暂时性病变损害了这项任务的性能。相比之下，这种病变并没有损害性能的非上下文嗅觉辨别任务。此外，vHC病变也损害了类似的上下文线索纹理辨别任务的性能，而AON病变只影响嗅觉上下文关联。我们描述了AON在嗅觉处理中的独特作用，并得出结论，早期的嗅觉网络，如嗅球和AON的功能作为多模态整合网络，而不是专门处理嗅觉信号。
Learning to associate the context in which a stimulus occurs is an important aspect of animal learning. We propose that the association of an olfactory stimulus with its multisensory context is mediated by projections from ventral hippocampal networks (vHC) to the anterior olfactory nucleus (AON). Using a contextually-cued olfactory discrimination task, rats were trained to associate two olfactory stimuli with different responses depending on visuo-spatial context. Temporary lesions of the AON or vHC impaired performance on this task. In contrast, such lesions did not impair performance on a non-contextual olfactory discrimination task. Moreover, vHC lesions also impaired performance on an analogous contextually-cued texture discrimination task, whereas AON lesions affected only olfactory contextual associations. We describe a distinct role for the AON in olfactory processing, and conclude that early olfactory networks such as the olfactory bulb and AON function as multimodal integration networks rather than processing olfactory signals exclusively.
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影响因子：
2.5
作者：
HABERLY, LB;PRICE, JL
通讯作者：
PRICE, JL
DOI：
10.3389/fneng.2011.00021
发表时间：
2011-11-16
期刊：
Frontiers in neuroengineering
影响因子：
--
作者：
Cleland TA;Chen SY;Hozer KW;Ukatu HN;Wong KJ;Zheng F
通讯作者：
Zheng F
DOI：
10.1523/jneurosci.5458-12.2013
发表时间：
2013-05-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Komorowski RW;Garcia CG;Wilson A;Hattori S;Howard MW;Eichenbaum H
通讯作者：
Eichenbaum H
影响因子：
7.8
作者：
Linster, C;Cleland, TA
通讯作者：
Cleland, TA
影响因子：
2.5
作者：
Kay, Rachel B.;Meyer, Elizabeth Amory;Illig, Kurt R.;Brunjes, Peter C.
通讯作者：
Brunjes, Peter C.