Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature.
Prognostic significance of tumor-associated macrophages in solid tumor: a meta-analysis of the literature.
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DOI：
10.1371/journal.pone.0050946
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Wei YQ
中科院分区：
文献类型：
--
作者：
Zhang QW;Liu L;Gong CY;Shi HS;Zeng YH;Wang XZ;Zhao YW;Wei YQ
肿瘤相关巨噬细胞(TAMs)被认为对肿瘤生长既有负面影响也有正面影响。对实体瘤患者生存的预后价值仍存在争议。我们对55项研究(n = 8,692例患者)进行了荟萃分析，以评估(免疫组织化学检测)与临床分期、总生存期(OS)和无病生存期(DFS)的相关性。同时观察了M1、M2型(n = 5)对存活率的影响。的高密度与乳腺癌[RR = 1.2 0(95%可信区间1.14~1.2 8)]和膀胱癌[RR = 3.30(95%CI，1.5 6~6.96)]和卵巢癌患者早期临床分期[RR = 0.5 2(95%CI，0.35~0.77)]显著相关。胃癌[RR = 1.6 4(95%CI，1.2 4-2.16)]、乳腺癌[RR = 8.6 2(95%CI，3.10-2 3.95)]、膀胱癌[RR = 5.0 0(95%CI，1.98-12.6 3)]、卵巢癌[RR = 2.5 5(95%CI，1.6 0-4.0 6)]、口腔癌[RR = 2.0 3(95%CI，和甲状腺癌[RR = 2.72(95%CI，1.2 6~5.86)]，结直肠癌患者的RR = 为0.6 4(95%CI，0.43~0.96)。与DFS之间无显著差异。的两种表型对存活率也没有显著影响。虽然不能排除一些适度的偏见，但的高密度似乎与胃癌、泌尿生殖道癌和头颈癌患者的OS较差有关，而与结直肠癌患者的OS较好相关。
Tumor associated macrophages (TAMs) are considered with the capacity to have both negative and positive effects on tumor growth. The prognostic value of TAM for survival in patients with solid tumor remains controversial. We conducted a meta-analysis of 55 studies (n = 8,692 patients) that evaluated the correlation between TAM (detected by immunohistochemistry) and clinical staging, overall survival (OS) and disease free survival (DFS). The impact of M1 and M2 type TAM (n = 5) on survival was also examined. High density of TAM was significantly associated with late clinical staging in patients with breast cancer [risk ratio (RR) = 1.20 (95% confidence interval (CI), 1.14–1.28)] and bladder cancer [RR = 3.30 (95%CI, 1.56–6.96)] and with early clinical staging in patients with ovarian cancer [RR = 0.52 (95%CI, 0.35–0.77)]. Negative effects of TAM on OS was shown in patients with gastric cancer [RR = 1.64 (95%CI, 1.24–2.16)], breast cancer [RR = 8.62 (95%CI, 3.10–23.95)], bladder cancer [RR = 5.00 (95%CI, 1.98–12.63)], ovarian cancer [RR = 2.55 (95%CI, 1.60–4.06)], oral cancer [RR = 2.03 (95%CI, 1.47–2.80)] and thyroid cancer [RR = 2.72 (95%CI, 1.26–5.86)],and positive effects was displayed in patients with colorectal cancer [RR = 0.64 (95%CI, 0.43–0.96)]. No significant effect was showed between TAM and DFS. There was also no significant effect of two phenotypes of TAM on survival. Although some modest bias cannot be excluded, high density of TAM seems to be associated with worse OS in patients with gastric cancer, urogenital cancer and head and neck cancer, with better OS in patients with colorectal cancer.
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影响因子：
2.6
作者：
Hanada, T;Nakagawa, M;Nomura, Y
通讯作者：
Nomura, Y
影响因子：
4.2
作者：
Kawahara, Akihiko;Hattori, Satoshi;Ono, Mayumi
通讯作者：
Ono, Mayumi
影响因子：
5.6
作者：
Espinosa, Inigo;Jose Carnicer, Maria;Prat, Jaime
通讯作者：
Prat, Jaime
影响因子：
6.2
作者：
Khorana, AA;Ryan, CK;Sahasrabudhe, DM
通讯作者：
Sahasrabudhe, DM
肿瘤浸润巨噬细胞密度高预示原发性肝细胞癌切除后预后不良
影响因子：
3.3
作者：
Ding, Tong;Xu, Jing;Zheng, Limin
通讯作者：
Zheng, Limin