Elimination of unfit cells maintains tissue health and prolongs lifespan.
Elimination of unfit cells maintains tissue health and prolongs lifespan.
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DOI：
10.1016/j.cell.2014.12.017
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发表时间：
2015-01-29
期刊：
影响因子：
64.5
通讯作者：
Moreno E
中科院分区：
文献类型：
--
作者：
Merino MM;Rhiner C;Lopez-Gay JM;Buechel D;Hauert B;Moreno E
有活力但受损的细胞可以在发育和衰老过程中积累。虽然消除这些细胞可能有益于器官功能，但识别这种不太适合的细胞群仍然具有挑战性。以前，我们确定了一种分子机制，基于“健身指纹”显示在细胞膜上，这使得直接健身比较果蝇细胞。在这里，我们研究了整个生物体的有效细胞选择的生理后果。我们发现，在果蝇中，基于健康的细胞剔除自然地用于维持组织健康，延缓衰老和延长寿命。我们确定了一个基因，azot，它确保消除不太适合的细胞。缺乏氮素会增加形态畸形和对随机突变的易感性，并加速组织变性。相反，提高细胞选择的效率有利于组织健康并延长寿命。基于适应性的细胞剔除维持组织健康Azot确保消除不太适合的细胞缺乏Azot加速组织退化提高细胞选择的效率延长寿命通过细胞适应性检查点Azot的表达确保消除不太适合的细胞，对于维持组织健康和延长果蝇的寿命很重要。
Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on “fitness fingerprints” displayed on cell membranes, which allows direct fitness comparison among cells in Drosophila. Here, we study the physiological consequences of efficient cell selection for the whole organism. We find that fitness-based cell culling is naturally used to maintain tissue health, delay aging, and extend lifespan in Drosophila. We identify a gene, azot, which ensures the elimination of less fit cells. Lack of azot increases morphological malformations and susceptibility to random mutations and accelerates tissue degeneration. On the contrary, improving the efficiency of cell selection is beneficial for tissue health and extends lifespan. Fitness-based cell culling maintains tissue health Azot ensures the elimination of less fit cells Lack of azot accelerates tissue degeneration Improving the efficiency of cell selection extends lifespan Elimination of less fit cells ensured by the expression of a cell-fitness checkpoint, Azot, is important for maintaining tissue health and prolonging lifespan in Drosophila.
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影响因子：
64.5
作者：
López-Otín C;Blasco MA;Partridge L;Serrano M;Kroemer G
通讯作者：
Kroemer G
影响因子：
64.5
作者：
Moreno, E;Basler, K
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通讯作者：
Weir, Bruce S.
影响因子：
2.5
作者：
de Beco, Simon;Ziosi, Marcello;Johnston, Laura A.
通讯作者：
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