Glia unglued: how signals from the extracellular matrix regulate the development of myelinating glia.
Glia unglued: how signals from the extracellular matrix regulate the development of myelinating glia.
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DOI：
10.1002/dneu.20966
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发表时间：
2011-11
影响因子：
3
通讯作者：
Tzvetanova ID
中科院分区：
文献类型：
--
作者：
Colognato H;Tzvetanova ID
神经系统的健康和功能依赖于神经胶质细胞，这些细胞用一种称为髓磷脂的特化质膜包裹神经元轴突。神经胶质细胞用髓磷脂靶向并包裹轴突的分子机制才刚刚开始被阐明，但一些研究表明细胞外基质蛋白及其受体是重要的外源调节因子。本文综述了细胞外基质蛋白及其受体在雪旺细胞和少突胶质细胞（分别是PNS和CNS的髓鞘胶质）的细胞发育过程中的多个步骤，以及髓鞘本身的构建和维持。第一部分描述了受特定细胞外基质蛋白和受体影响的相关细胞事件，包括层粘连蛋白、胶原蛋白、整合素和糖酐。第二部分描述了已被证明位于雪旺细胞和少突胶质细胞外基质受体下游的信号通路和效应分子，包括FAK、小Rho GTPases、ILK和PI3K/Akt通路，以及这些信号介质的作用。总之，我们强调细胞外基质蛋白作为环境传感器的概念，其作用是整合或匹配细胞反应，特别是对生长因子下游的细胞反应，以适当的基质附着。
The health and function of the nervous system relies on glial cells that ensheath neuronal axons with a specialized plasma membrane termed myelin. The molecular mechanisms by which glial cells target and enwrap axons with myelin are only beginning to be elucidated, yet several studies have implicated extracellular matrix proteins and their receptors as being important extrinsic regulators. This review provides an overview of the extracellular matrix proteins and their receptors that regulate multiple steps in the cellular development of Schwann cells and oligodendrocytes, the myelinating glia of the PNS and CNS, respectively, as well as in the construction and maintenance of the myelin sheath itself. The first part describes the relevant cellular events that are influenced by particular extracellular matrix proteins and receptors, including laminins, collagens, integrins, and dystroglycan. The second part describes the signaling pathways and effector molecules that have been demonstrated to be downstream of Schwann cell and oligodendroglial extracellular matrix receptors, including FAK, small Rho GTPases, ILK, and the PI3K/Akt pathway, and the roles that have been ascribed to these signaling mediators. Throughout, we emphasize the concept of extracellular matrix proteins as environmental sensors that act to integrate, or match, cellular responses, in particular to those downstream of growth factors, to appropriate matrix attachment.
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影响因子：
11.4
作者：
Baron, W;Shattil, SJ;ffrench-Constant, C
通讯作者：
ffrench-Constant, C
影响因子：
9.2
作者：
Baron, W;Decker, L;ffrench-Constant, C
通讯作者：
ffrench-Constant, C
影响因子：
5.3
作者：
Arai, Ken;Lo, Eng H.
通讯作者：
Lo, Eng H.
DOI：
10.1097/00005072-197511000-00006
发表时间：
1975-01-01
影响因子：
3.2
作者：
BRAY, GM;AGUAYO, AJ
通讯作者：
AGUAYO, AJ
影响因子：
3
作者：
Baeten, Kim M.;Akassoglou, Katerina
通讯作者：
Akassoglou, Katerina