Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials.
Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials.
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骨生物活性材料调控间充质干细胞命运的检测方法的建立。
DOI：
10.1016/j.bioactmat.2020.08.035
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发表时间：
2021-03
影响因子：
18.9
通讯作者：
Xiaodan S
中科院分区：
文献类型：
--
作者：
Le J;Zhongqun L;Zhaoyan W;Yijun S;Yingjin W;Yaojie W;Yanan J;Zhanrong J;Chunyang M;Fangli G;Nan X;Lingyun Z;Xiumei W;Qiong W;Xiong L;Xiaodan S
间充质干细胞（mesenchymal stem cells，MSCs）的命运受生物、物理和化学信号的调控。生物技术和材料科学的发展促进了生物活性材料的出现，这些材料可以为MSCs提供物理和化学信号，以调节其命运。为了设计和合成能够精确调控间充质干细胞命运的材料，需要明确材料性质与间充质干细胞命运之间的关系，其中对间充质干细胞命运的检测起着重要作用。在过去的30年里，人们开发了一系列检测技术来检测生物活性材料调控的MSC的命运，其中高通量技术由于能够一次性检测大量数据而显示出巨大的优势。本文从传统技术到高通量技术，系统地综述了骨生物活性材料（bone biological materials，BBM）调控MSCs命运的最新研究进展。最后对BBM调控MSCs命运的检测技术存在的问题和未来的发展方向进行了展望。本文旨在为研究者建立BBM的性质与MSCs命运之间的关系提供一个检测技术框架，从而帮助研究者更好地设计和合成能够精确调控MSCs命运的BBM。骨髓基质细胞的命运可以通过骨生物活性材料（BBM）来调节。本文对BBM调控的MSCs命运的传统检测技术和高通量检测技术进行了全面系统的综述。为了设计和合成能够精确调控间充质干细胞命运的材料，需要阐明材料性质与间充质干细胞命运之间的关系。最后对BBM调控MSCs命运的检测技术存在的问题和未来的发展方向进行了展望。本文旨在为研究者建立BBM的性质与MSCs命运之间的关系提供一个检测技术框架，从而帮助研究者更好地设计和合成能够精确调控MSCs命运的BBM。
The fate of mesenchymal stem cells (MSCs) is regulated by biological, physical and chemical signals. Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their fate. In order to design and synthesize materials that can precisely regulate the fate of MSCs, the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified, in which the detection of the fate of mesenchymal stem cells plays an important role. In the past 30 years, a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials, among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one time. In this review, the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials (BBMs) are systematically reviewed from traditional technology to high-throughput technology which is emphasized especially. Moreover, current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected. The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs, so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs. The fate of MSCs can be regulated by bone bioactive materials (BBMs). Herein, traditional technology and highthroughput technology which can be used to detect the fate of MSCs regulated by BBMs are reviewed comprehensively and systematically. In order to design and synthesize materials that can precisely regulate the fate of MSCs, the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified. Current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected. •The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs, so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs.
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