The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction.
The somatosensory link in fibromyalgia: functional connectivity of the primary somatosensory cortex is altered by sustained pain and is associated with clinical/autonomic dysfunction.
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DOI：
10.1002/art.39043
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发表时间：
2015-05
影响因子：
13.3
通讯作者：
Napadow, Vitaly
中科院分区：
文献类型：
--
作者：
Kim, Jieun;Loggia, Marco L.;Cahalan, Christine M.;Harris, Richard E.;Beissner, Florian;Garcia, Ronald G.;Kim, Hyungjun;Barbieri, Riccardo;Wasan, Ajay D.;Edwards, Robert R.;Napadow, Vitaly
纤维肌痛（FM）是一种慢性功能性疼痛综合征，其特征是广泛的疼痛，显著的疼痛灾难性，交感迷走神经功能障碍，以及诱发疼痛的放大的时间总和。虽然有几项研究已经发现FM中静息脑连接的改变，但研究尚未专门探讨躯体感觉系统及其在躯体和非躯体FM神经病学中的作用。我们的目的是评估静息状态下初级体感皮层（S1）的连通性，并探讨持续的、诱发的深层组织疼痛如何调节这种连通性。我们采集了FM患者和健康对照组（HC）在休息（REST）和下肢持续机械性压迫疼痛（Pain）期间的fMRI和心电图数据。计算与不同S1亚区相关的功能连接，而S1 leg（腿部代表）连接是REST和Pain之间的对比，并与FM中的临床相关测量相关。在静息状态下，FM显示多个同侧和跨半球S1亚区之间的连接性降低，这与临床疼痛严重程度相关。与静息状态相比，疼痛可增加FM患者S1腿与双侧前屈肌的连接，但在HC中无此作用。此外，在FM中，持续疼痛改变的S1 leg与前额叶的连接与临床/行为疼痛测量和自主神经反应相关。我们的研究表明，FM中的躯体和非躯体功能障碍，包括临床疼痛，疼痛灾难化，自主神经功能障碍和放大的时间总和，都与诱发的深层组织疼痛改变S1连接到显着性/情感疼痛处理区域的程度密切相关。此外，FM中静息状态下S1亚区之间的连接性减弱可能是由于持续广泛的临床疼痛所致。
Fibromyalgia (FM) is a chronic functional pain syndrome characterized by widespread pain, significant pain catastrophizing, sympathovagal dysfunction, and amplified temporal summation for evoked pain. While several studies have found altered resting brain connectivity in FM, studies have not specifically probed the somatosensory system, and its role in both somatic and non-somatic FM symptomatology. Our objective was to evaluate resting primary somatosensory cortex (S1) connectivity, and explore how sustained, evoked deep-tissue pain modulates this connectivity. We acquired fMRI and electrocardiography data from FM patients and healthy controls (HC) during rest (REST) and sustained mechanical pressure pain (PAIN) over the lower leg. Functional connectivity associated with different S1 subregions was calculated, while S1leg (leg representation) connectivity was contrast between REST and PAIN, and correlated with clinically-relevant measures in FM. At REST, FM showed decreased connectivity between multiple ipsilateral and cross-hemispheric S1 subregions, which was correlated with clinical pain severity. PAIN, compared to REST, produced increased S1legconnectivity to bilateral anterior insula in FM, but not in HC. Moreover, in FM, sustained pain-altered S1legconnectivity to anterior insula was correlated with clinical/behavioral pain measures and autonomic responses. Our study demonstrates that both somatic and non-somatic dysfunction in FM, including clinical pain, pain catastrophizing, autonomic dysfunction, and amplified temporal summation, are all closely linked with the degree to which evoked deep-tissue pain alters S1 connectivity to salience/affective pain processing regions. Additionally, diminished connectivity between S1 subregions at REST in FM may result from ongoing widespread clinical pain.
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DOI：
10.1523/jneurosci.1984-11.2011
发表时间：
2011-09-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Baliki MN;Baria AT;Apkarian AV
通讯作者：
Apkarian AV
影响因子：
3.4
作者：
Kim, Jieun;Van Dijk, Koene R. A.;Napadow, Vitaly
通讯作者：
Napadow, Vitaly
纤维肌痛中与疼痛相关的奖励/惩罚的破坏脑电路。
DOI：
10.1002/art.38191
发表时间：
2014-01
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Loggia ML;Berna C;Kim J;Cahalan CM;Gollub RL;Wasan AD;Harris RE;Edwards RR;Napadow V
通讯作者：
Napadow V
影响因子：
7.4
作者：
Loggia ML;Kim J;Gollub RL;Vangel MG;Kirsch I;Kong J;Wasan AD;Napadow V
通讯作者：
Napadow V
影响因子：
5.7
作者：
Duerden, Emma G.;Arsalidou, Marie;Taylor, Margot J.
通讯作者：
Taylor, Margot J.