Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling.
Acute Cycling Exercise Induces Changes in Red Blood Cell Deformability and Membrane Lipid Remodeling.
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DOI：
10.3390/ijms22020896
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发表时间：
2021-01-18
影响因子：
5.6
通讯作者：
D'Alessandro A
中科院分区：
文献类型：
--
作者：
Nemkov T;Skinner SC;Nader E;Stefanoni D;Robert M;Cendali F;Stauffer E;Cibiel A;Boisson C;Connes P;D'Alessandro A
在这里，我们描述了一个受控的，30分钟，高强度循环试验对血液流变学和代谢的红细胞（红细胞）和血浆从训练有素的男性的影响。红细胞在试验后表现出变形能力下降和微粒生成增加的趋势。同时，代谢组学和脂质组学强调了氧化应激和膜脂重塑机制的激活，以应对循环试验中体力消耗导致的循环特性改变。值得注意的是，从辅酶A （CoA）合成到脂肪酰基链的中间产物，与肉毒碱和酰基肉毒碱的可逆转化平行，作为代谢产物出现，与红细胞变形能力和运动中微粒的产生显著相关。综上所述，我们认为红细胞膜重塑和修复通过改变红细胞特性在运动的生理反应中起着积极的作用。
Here we describe the effects of a controlled, 30 min, high-intensity cycling test on blood rheology and the metabolic profiles of red blood cells (RBCs) and plasma from well-trained males. RBCs demonstrated decreased deformability and trended toward increased generation of microparticles after the test. Meanwhile, metabolomics and lipidomics highlighted oxidative stress and activation of membrane lipid remodeling mechanisms in order to cope with altered properties of circulation resulting from physical exertion during the cycling test. Of note, intermediates from coenzyme A (CoA) synthesis for conjugation to fatty acyl chains, in parallel with reversible conversion of carnitine and acylcarnitines, emerged as metabolites that significantly correlate with RBC deformability and the generation of microparticles during exercise. Taken together, we propose that RBC membrane remodeling and repair plays an active role in the physiologic response to exercise by altering RBC properties.
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影响因子：
10.1
作者：
D'Alessandro A;Fu X;Kanias T;Reisz JA;Culp-Hill R;Guo Y;Gladwin MT;Page G;Kleinman S;Lanteri M;Stone M;Busch MP;Zimring JC;Recipient Epidemiology and Donor Evaluation Study-III (REDS III)
通讯作者：
Recipient Epidemiology and Donor Evaluation Study-III (REDS III)
影响因子：
4.3
作者：
Enea, C.;Seguin, F.;Dugue, B.
通讯作者：
Dugue, B.
影响因子：
2.1
作者：
Chaar, Vicky;Romana, Marc;Connes, Philippe
通讯作者：
Connes, Philippe
影响因子：
4.6
作者：
Buerck, James P.;Burke, Dustin K.;O'Rear, Edgar A.
通讯作者：
O'Rear, Edgar A.
影响因子：
2.9
作者：
D'Alessandro A;Fu X;Reisz JA;Kanias T;Page GP;Stone M;Kleinman S;Zimring JC;Busch M;Recipient Epidemiology and Donor Evaluation Study-III (REDS III)
通讯作者：
Recipient Epidemiology and Donor Evaluation Study-III (REDS III)