Statistical Nonparametric fMRI Maps in the Analysis of Response Inhibition in Abstinent Individuals with History of Alcohol Use Disorder.
Statistical Nonparametric fMRI Maps in the Analysis of Response Inhibition in Abstinent Individuals with History of Alcohol Use Disorder.
复制标题
DOI：
10.3390/bs12050121
复制
发表时间：
2022-04-21
影响因子：
2.6
通讯作者：
Porjesz, Bernice
中科院分区：
文献类型：
--
作者：
Pandey, Ashwini Kumar;Ardekani, Babak Assai;Byrne, Kelly Nicole-Helen;Kamarajan, Chella;Zhang, Jian;Pandey, Gayathri;Meyers, Jacquelyn Leigh;Kinreich, Sivan;Chorlian, David Balin;Kuang, Weipeng;Stimus, Arthur T.;Porjesz, Bernice
关键词：
酒精使用障碍（AUD）患者戒酒后，抑制性损伤可能持续存在。传统的统计参数映射（SPM） fMRI分析需要数据满足参数假设，而这些假设在大脑等生物物理系统中往往难以满足，研究报告了对负责反应抑制的大脑区域的模棱两可的发现，并且在AUD中发现的抑制期间的激活异常在戒断后持续存在。研究需要使用更新的分析方法。在Go/NoGo任务期间，对30名禁欲的男性AUD参与者和30名健康的对照参与者进行了fMRI扫描，目的是：(1)使用严格的基于非参数排列的fMRI分析来表征与反应抑制相关的神经元基质，(2)确定这些区域在禁欲的AUD参与者和对照参与者之间是否存在差异激活。血氧水平依赖性对比分析显示，在成功抑制期间，几个右侧皮质区域显著激活，一些左侧皮质区域失活。激活水平差异的最大来源是组间差异。这些发现提供了在反应抑制过程中使用皮层底物的证据。最大的差异可以解释为AUD患者的抑制和腹侧注意皮质网络的激活较低，这与禁欲时间、年龄或冲动无关。
Inhibitory impairments may persist after abstinence in individuals with alcohol use disorder (AUD). Using traditional statistical parametric mapping (SPM) fMRI analysis, which requires data to satisfy parametric assumptions often difficult to satisfy in biophysical system as brain, studies have reported equivocal findings on brain areas responsible for response inhibition, and activation abnormalities during inhibition found in AUD persist after abstinence. Research is warranted using newer analysis approaches. fMRI scans were acquired during a Go/NoGo task from 30 abstinent male AUD and 30 healthy control participants with the objectives being (1) to characterize neuronal substrates associated with response inhibition using a rigorous nonparametric permutation-based fMRI analysis and (2) to determine whether these regions were differentially activated between abstinent AUD and control participants. A blood oxygen level dependent contrast analysis showed significant activation in several right cortical regions and deactivation in some left cortical regions during successful inhibition. The largest source of variance in activation level was due to group differences. The findings provide evidence of cortical substrates employed during response inhibition. The largest variance was explained by lower activation in inhibition as well as ventral attentional cortical networks in abstinent individuals with AUD, which were not found to be associated with length of abstinence, age, or impulsiveness.
登录
查看更多内容
推理，学习和创造力：额叶功能和人类决策。
影响因子：
9.8
作者：
Collins A;Koechlin E
通讯作者：
Koechlin E
影响因子：
2.8
作者：
Ando, Balint;Must, Anita;Almos, Peter Z.
通讯作者：
Almos, Peter Z.
影响因子：
4.8
作者：
Chevrier, Andre D.;Noseworthy, Michael D.;Schachar, Russell
通讯作者：
Schachar, Russell
影响因子：
9.9
作者：
Cox, Simon R.;Dickie, David Alexander;Deary, Ian J.
通讯作者：
Deary, Ian J.
影响因子：
5.7
作者：
Eklund, Anders;Andersson, Mats;Knutsson, Hans
通讯作者：
Knutsson, Hans