Role of sex hormones in modulating breast and ovarian cancer associated pain.
Role of sex hormones in modulating breast and ovarian cancer associated pain.
复制标题
DOI：
10.1016/j.mce.2021.111320
复制
发表时间：
2021-08-01
影响因子：
4.1
通讯作者：
Guindon J
中科院分区：
文献类型：
--
作者：
McHann MC;Blanton HL;Guindon J
根据美国国家癌症研究所的数据，到2020年，估计将有21750例新的卵巢癌病例和276480例新的乳腺癌病例。乳腺癌和卵巢癌都是激素依赖型癌症，这意味着它们在没有激素存在的情况下无法生长。在这两种癌症中，研究最多的两种激素是雌激素和黄体酮，它们也参与疼痛的调节。乳腺癌和卵巢癌的疼痛发生率非常高。关于激素调节疼痛的机制的研究仍然存在争议，因为一些研究发现雌激素在疼痛研究中具有抗伤害性，而另一些研究发现雌激素具有促伤害性。此外，对乳腺癌和卵巢癌相关疼痛的镇痛治疗是有限的，而且往往无效。在这篇综述中，我们将重点讨论雌激素和孕激素在调节疼痛和癌症中的作用机制。我们还将讨论这些类型的癌症和相关疼痛的新治疗方案。
According to the National Cancer Institute in 2020 there will be an estimated 21,750 new ovarian cancer cases and 276,480 new breast cancer cases. Both breast and ovarian cancer are hormone dependent cancers, meaning they cannot grow without the presence of hormones. The two most studied hormones in these two cancers are estrogen and progesterone, which are also involved in the modulation of pain. The incidence of pain in breast and ovarian cancer is very high. Research about mechanisms involved in modulation of pain by hormones are still being debated, as some studies find estrogen to be anti-nociceptive and others pro-nociceptive in pain studies. Moreover, analgesic treatments for breast and ovarian cancer-associated pain are limited and often ineffective. In this review, we will focus on estrogen and progesterone mechanisms of action in modulation of pain and cancer. We will also discuss new treatment options for these types of cancer and associated-pain.
登录
查看更多内容
影响因子：
7.4
作者：
Borsook D;Youssef AM;Simons L;Elman I;Eccleston C
通讯作者：
Eccleston C
影响因子：
1
作者：
de Araujo Palmeira, Claudia Carneiro;Ashmawi, Hazem Adel;Posso, Irimar de Paula
通讯作者：
Posso, Irimar de Paula
影响因子：
3.1
作者：
Bovbjerg, Dana H.;Keefe, Francis J.;Shelby, Rebecca A.
通讯作者：
Shelby, Rebecca A.
DOI：
10.14694/edbk_180469
发表时间：
2017-01-01
期刊：
American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
影响因子：
--
作者：
Bennett, Mike;Paice, Judith A;Wallace, Mark
通讯作者：
Wallace, Mark
影响因子：
3.3
作者：
Chaban, VV;Mayer, EA;Micevych, PE
通讯作者：
Micevych, PE