Functional nanoarrays for investigating stem cell fate and function.
Functional nanoarrays for investigating stem cell fate and function.
复制标题
DOI：
10.1039/c9nr10963c
复制
发表时间：
2020-05-07
期刊：
影响因子：
6.7
通讯作者：
Choi JW
中科院分区：
文献类型：
--
作者：
Lee JH ;Luo J ;Choi HK ;Chueng SD ;Lee KB ;Choi JW
干细胞在组织工程和再生医学领域提供了极好的潜力，这是基于它们不仅自我更新而且分化成感兴趣的专门细胞类型的优异能力。然而，缺乏非破坏性监测系统使得在移植前识别和表征分化细胞而不损害细胞活力具有挑战性。因此，非常需要开发用于分析细胞功能的非破坏性监测方法，并且该方法可以显著有益于基于干细胞的疗法。最近，基于纳米材料的支架（例如，纳米阵列）在控制干细胞的分化和实时灵敏地表征分化状态方面取得了相当大的进展。本文综述了纳米阵列的合成方法及其在干细胞命运调控和电化学监测活细胞功能方面的应用。我们相信，在这篇评论中讨论的主题可以提供一个简短和简洁的指导方针，在新的纳米阵列的发展，并促进在活细胞研究应用的兴趣。这种既能控制又能监测干细胞命运和功能的方法将是一种有前途的技术，可以加速干细胞治疗。综述了纳米阵列的合成及其在干细胞命运控制和活细胞功能监测中的应用。
Stem cells offers excellent potential in the field of tissue engineering and regenerative medicine based on their excellent capability to not only self-renew but also differentiate into a specialized cell type of interest. However, the lack of a non-destructive monitoring system renders it challenging to identify and characterize differentiated cells before their transplantation without compromising cell viability. Thus, the development of a non-destructive monitoring method for analyzing cell function is highly desired and can significantly benefit stem cell-based therapies. Recently, nanomaterial-based scaffolds (e.g., nanoarray) have made possible considerable advances in controlling the differentiation of stem cells and characterization ofing the differentiation status sensitively in realtime. This review provides a selective overview of the recent progress in synthesis methods of nanoarray as well as its applications for controlling stem cell fate and monitoring live cell functions electrochemically. We believe the topics discussed in this review can provide a brief and concise guideline in the development of novel nanoarrays and promote the interest in live cell study applications. The A method which that can not only control but also monitor stem cell fate and function will be a promising technology that can accelerate stem cell therapies. Overview of the recent progress of nanoarray synthesis and applications for controlling stem cell fate and monitoring live cell functions.
登录
查看更多内容
DOI：
10.1126/science.1247391
发表时间：
2014-08-22
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Fox IJ;Daley GQ;Goldman SA;Huard J;Kamp TJ;Trucco M
通讯作者：
Trucco M
影响因子：
3.3
作者：
Sophia Fox AJ;Bedi A;Rodeo SA
通讯作者：
Rodeo SA
影响因子：
11.7
作者：
El-Said WA;Yoon J;Choi JW
通讯作者：
Choi JW
影响因子：
4.6
作者：
Gerardo, Heloisa;Lima, Ana;Graos, Mario
通讯作者：
Graos, Mario
影响因子：
14
作者：
Abagnale, Giulio;Steger, Michael;Wagner, Wolfgang
通讯作者：
Wagner, Wolfgang