Investigating the influence of an effort-reward interaction on cognitive fatigue in individuals with multiple sclerosis.
Investigating the influence of an effort-reward interaction on cognitive fatigue in individuals with multiple sclerosis.
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DOI：
10.1111/jnp.12295
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发表时间：
2023-06
影响因子：
2.2
通讯作者：
Medaglia, John D.
中科院分区：
文献类型：
--
作者：
Erani, Fareshte;Patel, Darshan;Deck, Benjamin L.;Hamilton, Roy H.;Schultheis, Maria T.;Medaglia, John D.
这项研究探讨了努力-回报关系（一个基于认知神经科学的理论框架）的改变是否可以解释认知疲劳。40人MS和40名健康的年龄和教育相匹配的认知健康对照（HC）参加了一个计算机化的切换任务与正交的高，低需求（努力）和奖励操纵。我们使用视觉模拟疲劳量表（VAS-F）来评估任务期间每个条件之前和之后的主观状态疲劳。我们使用混合效应模型来估计努力和奖励之间的关联和相互作用以及它们与主观疲劳和任务绩效的关系。我们发现高需求条件与VAS-F评分增加（p<0.001），反应时间（RT）延长（p<0.001）和准确性降低（p<0.001）相关。高回报条件与更快的RT（p= 0.006）和更高的准确性（p= 0.03）相关。努力和奖励对VAS-F分数或绩效没有交互作用。MS参与者报告较高的VAS-F评分（p=.02）。在所有条件下，与HC相比，MS参与者的速度较慢（p<.001），并且作为条件需求的函数较慢（p<.001）。这项行为研究没有发现证据表明努力-回报互动与认知疲劳有关。然而，我们的研究结果支持努力在主观认知疲劳中的作用，以及努力和奖励对任务绩效的影响。在未来的研究中，更显着的奖励操纵可能是必要的，以确定主观认知疲劳的努力-奖励的相互作用。
This study examined whether an alteration in the effort-reward relationship, a theoretical framework based in cognitive neuroscience, could explain cognitive fatigue. Forty persons with MS and 40 healthy age- and education-matched cognitively healthy controls (HC) participated in a computerized switching task with orthogonal high- and low-demand (effort) and reward manipulations. We used the Visual Analog Scale of Fatigue (VAS-F) to assess subjective state fatigue before and after each condition during the task. We used mixed-effects models to estimate the association and interaction between effort and reward and their relationship to subjective fatigue and task performance. We found the high-demand condition was associated with increased VAS-F scores (p<.001), longer response times (RT) (p<.001), and lower accuracy (p<.001). The high-reward condition was associated with faster RT (p=.006) and higher accuracy (p=.03). There was no interaction effect between effort and reward on VAS-F scores or performance. Participants with MS reported higher VAS-F scores (p=.02). Across all conditions, participants with MS were slower (p<.001) and slower as a function of condition demand compared to HC (p<.001). This behavioral study did not find evidence that an effort-reward interaction is associated with cognitive fatigue. However, our findings support the role of effort in subjective cognitive fatigue and both effort and reward on task performance. In future studies, more salient reward manipulations could be necessary to identify effort-reward interactions on subjective cognitive fatigue.
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DOI：
10.3390/diagnostics10110930
发表时间：
2020-11-10
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Chen MH;DeLuca J;Genova HM;Yao B;Wylie GR
通讯作者：
Wylie GR
影响因子：
4.2
作者：
Angelides NH;Gupta J;Vickery TJ
通讯作者：
Vickery TJ
影响因子：
3.5
作者：
Huebner, Ronald;Schloesser, Jan
通讯作者：
Schloesser, Jan
影响因子：
14.5
作者：
Aron, AR;Monsell, S;Robbins, TW
通讯作者：
Robbins, TW
影响因子：
4.4
作者：
DeLuca, John;Genova, Helen M.;Wylie, Glenn
通讯作者：
Wylie, Glenn