Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study.
Common mental disorder and obesity: insight from four repeat measures over 19 years: prospective Whitehall II cohort study.
复制标题
DOI：
10.1136/bmj.b3765
复制
发表时间：
2009-10-06
期刊：
影响因子：
--
通讯作者：
Jokela M
中科院分区：
文献类型：
--
作者：
Kivimäki M;Lawlor DA;Singh-Manoux A;Batty GD;Ferrie JE;Shipley MJ;Nabi H;Sabia S;Marmot MG;Jokela M
目的研究常见精神障碍与肥胖之间潜在的相互关系，并评估是否存在剂量-反应关系。设计前瞻性队列研究，包括19年常见精神障碍和肥胖的四项测量(白厅II研究)。将公务员部门设在伦敦。参与者4363名成年人(28%为女性，基线平均年龄为44岁)。主要结果常见精神障碍被定义为一般健康问卷“干酪性”；超重和肥胖根据世界卫生组织的定义。结果在调整了基线时的年龄、性别和体重指数的模型中，与无常见精神障碍的人相比，在第一次、第二次或第三次筛查中，患有常见精神障碍的参与者在第四次筛查时肥胖的优势比分别为1.33(95%可信区间为1.001.001.77)、1.64%(1.132.36)和2.01%(1.213.34)(趋势P；0.001)。在最近一次筛查中，体重指数的相应平均差异分别为0.20、0.31和0.50(P<0.001)。在对与心理健康相关的基线特征进行调整并排除基线时肥胖的参与者后，这些相关性仍然存在。此外，肥胖预测未来患常见精神障碍的风险，同样有剂量-反应关系的证据(趋势P=0.02，多变量模型)。然而，当排除基线上有常见精神障碍的人时，这种联系就消失了(趋势P=0.33)。结论这些发现表明，在英国成年人中，常见的精神障碍与肥胖之间的关联方向是从常见的精神障碍到未来肥胖风险的增加。这种关联是累积的，因此患有慢性或反复发作常见精神障碍的人尤其有体重增加的风险。
Objectives To examine potential reciprocal associations between common mental disorders and obesity, and to assess whether dose-response relations exist. Design Prospective cohort study with four measures of common mental disorders and obesity over 19 years (Whitehall II study). Setting Civil service departments in London. Participants 4363 adults (28% female, mean age 44 years at baseline). Main outcome Common mental disorder defined as general health questionnaire “caseness;” overweight and obesity based on Word Health Organization definitions. Results In models adjusted for age, sex, and body mass index at baseline, odds ratios for obesity at the fourth screening were 1.33 (95% confidence interval 1.00 to 1.77), 1.64 (1.13 to 2.36), and 2.01 (1.21 to 3.34) for participants with common mental disorder at one, two, or three preceding screenings compared with people free from common mental disorder (P for trend<0.001). The corresponding mean differences in body mass index at the most recent screening were 0.20, 0.31, and 0.50 (P for trend<0.001). These associations remained after adjustment for baseline characteristics related to mental health and exclusion of participants who were obese at baseline. In addition, obesity predicted future risk of common mental disorder, again with evidence of a dose-response relation (P for trend=0.02, multivariable model). However, this association was lost when people with common mental disorder at baseline were excluded (P for trend=0.33). Conclusions These findings suggest that in British adults the direction of association between common mental disorders and obesity is from common mental disorder to increased future risk of obesity. This association is cumulative such that people with chronic or repeat episodes of common mental disorder are particularly at risk of weight gain.
登录
查看更多内容
影响因子：
4.9
作者：
Atlantis, E.;Baker, M.
通讯作者：
Baker, M.
影响因子：
10.6
作者：
Stunkard, AJ;Faith, MS;Allison, KC
通讯作者：
Allison, KC
影响因子：
--
作者：
Vogelzangs, Nicole;Kritchevsky, Stephen B.;Penninx, Brenda W. J. H.
通讯作者：
Penninx, Brenda W. J. H.
影响因子：
8
作者：
Goodman, E;Whitaker, RC
通讯作者：
Whitaker, RC
影响因子：
120.7
作者：
Golden, Sherita Hill;Lazo, Mariana;Lyketsos, Constantine
通讯作者：
Lyketsos, Constantine