Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019.
Origin and Spread of the Dengue Virus Type 1, Genotype V in Senegal, 2015-2019.
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DOI：
10.3390/v13010057
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发表时间：
2021-01-04
期刊：
影响因子：
--
通讯作者：
Sall AA
中科院分区：
文献类型：
--
作者：
Dieng I;Cunha M;Diagne MM;Sembène PM;Zanotto PMA;Faye O;Faye O;Sall AA
登革病毒(DENV)是最广泛传播的节肢动物传播病毒，近几十年来在全球范围内暴发的数量和严重程度都在增加。登革热是由基因上不同的血清型DENV-1-4引起的。在这里，我们提供了DENV-1的数据，这些数据是从2015-2019年塞内加尔和马里(西非)爆发的登革热患者中分离出来的，这些数据通过对包膜(E)基因的测序进行了分析。用最大似然法和贝叶斯方法推断了新城疫病毒在西非的出现和动态。DENV-1聚为一个单系群，与东南亚的DENV-1有密切的亲缘关系。该病毒似乎直接传入塞内加尔的麦地那古纳斯(达喀尔郊区)(位置概率=0.301，后验概率=0.76)。病毒在塞内加尔的传播发生在2014年左右(95%HPD=2012.88-2014.84)，随后病毒转移到塞内加尔境内的地区(例如卢加和法蒂克)，在随后的几年中造成了严重的疫情。该病毒似乎是在塞内加尔传入后在马里(邻国)传入的。总而言之，我们提出的证据表明，2015年后塞内加尔和马里城市环境中由DENV-1引起的疫情是由来自亚洲的单一病毒传入引起的。
Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1–4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015–2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88–2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia.
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DOI：
10.1126/science.aac5017
发表时间：
2015-09-18
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Katzelnick LC;Fonville JM;Gromowski GD;Bustos Arriaga J;Green A;James SL;Lau L;Montoya M;Wang C;VanBlargan LA;Russell CA;Thu HM;Pierson TC;Buchy P;Aaskov JG;Muñoz-Jordán JL;Vasilakis N;Gibbons RV;Tesh RB;Osterhaus AD;Fouchier RA;Durbin A;Simmons CP;Holmes EC;Harris E;Whitehead SS;Smith DJ
通讯作者：
Smith DJ
DOI：
10.3390/v3091562
发表时间：
2011-09
期刊：
Viruses
影响因子：
--
作者：
Chen R;Vasilakis N
通讯作者：
Vasilakis N
影响因子：
5.4
作者：
Cologna, R;Armstrong, PM;Rico-Hesse, R
通讯作者：
Rico-Hesse, R
DOI：
10.1016/s0923-2516(06)80135-4
发表时间：
1992-11-01
期刊：
RESEARCH IN VIROLOGY
影响因子：
--
作者：
DIGOUTTE, JP;CALVOWILSON, MA;ADAM, F
通讯作者：
ADAM, F
影响因子：
5.3
作者：
Martin DP;Murrell B;Golden M;Khoosal A;Muhire B
通讯作者：
Muhire B