Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome.
Metabolic dysfunction in obese Hispanic women with polycystic ovary syndrome.
复制标题
患有多囊卵巢综合征的肥胖西班牙裔女性的代谢功能障碍。
DOI：
10.1093/humrep/dev073
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Mazzone,Theodore
中科院分区：
文献类型：
--
作者：
Sam,Susan;Scoccia,Bert;Yalamanchi,Sudha;Mazzone,Theodore
研究问题：某些多囊卵巢综合征（PCOS）患者的代谢紊乱风险增加吗？在美国，肥胖的西班牙裔多囊卵巢综合征女性与年龄和bmi匹配的肥胖非西班牙裔白人多囊卵巢综合征女性相比，代谢紊乱的风险增加。已知情况：不同种族在身体组成和代谢风险方面的差异是众所周知的。多囊卵巢综合征是育龄妇女的一种常见疾病，与胰岛素抵抗、葡萄糖耐受不良和血脂异常的高发率有关。研究设计、规模、持续时间在某学术医学中心对60名育龄多囊卵巢综合征妇女进行了横断面观察性研究。参与者/材料、环境、方法：从年龄和BMI相似的17名西班牙裔、22名非西班牙裔黑人和21名非西班牙裔白人多囊卵巢综合征女性禁食后获得血液。比较三组之间的人体测量参数、胰岛素、脂质和脂蛋白水平（核磁共振测量）。主要结果和变化和BMI的作用在两组之间没有差异。与非西班牙裔白人女性相比，患有多囊卵巢综合征的西班牙裔女性腰臀比（WHR）更高（P= 0.02），胰岛素抵抗稳态模型评估（HOMA-IR） （P= 0.03）和更具有动脉粥样硬化性的脂质和脂蛋白谱，包括较低的高密度脂蛋白（HDL） （P= 0.02），较高的低密度脂蛋白（LDL）颗粒数（P= 0.02），较高的极低密度脂蛋白颗粒（VLDL）大小（P= 0.03）和较低的LDL （P= 0.03）和HDL颗粒大小（P= 0.005）。调整WHR后，HDL、HOMA-IR、VLDL和LDL大小的差异不存在，而LDL颗粒数（P= 0.04）和HDL大小（P= 0.01）的差异持续存在。局限性，注意原因三组的样本量很小，但研究结果仍然很重要。这些女性大多是肥胖的，所以代谢紊乱的种族差异可能不适用于患有多囊卵巢综合征的非肥胖女性。研究结果的更广泛意义：与BMI、肥胖、生育年龄无关，美国西班牙裔多囊卵巢综合征女性有更大程度的腹部肥胖、胰岛素抵抗和血脂异常。西班牙裔多囊卵巢综合征妇女可能受益于更集中的代谢参数管理。研究经费/竞争利益(S)本项目由以下国家卫生研究院资助：K23 DK080988-01A1给S.S.和UL1RR029879给伊利诺伊大学CTSA。没有作者报告有任何利益冲突。
STUDY QUESTIONAre certain ethnic groups with polycystic ovary syndrome (PCOS) at increased risk of metabolic disorders?SUMMARY ANSWERObese Hispanic women with PCOS are at increased risk of metabolic disorders compared with age- and BMI-matched obese non-Hispanic white women with PCOS in the USA.WHAT IS KNOWN ALREADYEthnic differences in body composition and metabolic risk are well established. PCOS is a common disorder in women of reproductive age and is associated with high rates of insulin resistance, glucose intolerance and dyslipidemia.STUDY DESIGN, SIZE, DURATIONA cross-sectional observational study was performed at an Academic Medical Center on 60 women of reproductive age with PCOS.PARTICIPANTS/MATERIALS, SETTING, METHODSBlood was obtained after fasting from 17 Hispanic, 22 non-Hispanic black and 21 non-Hispanic white women with PCOS who were similar in age and BMI. Anthropometric parameters, insulin, lipid and lipoprotein levels (measured by nuclear magnetic resonance) were compared between the three groups.MAIN RESULTS AND THE ROLE OF CHANCEAge and BMI did not differ between the groups. Hispanic women with PCOS had higher waist-to-hip ratio (WHR) (P= 0.02), homeostasis model assessment of insulin resistance (HOMA-IR) (P= 0.03) and a more atherogenic lipid and lipoprotein profile consisting of lower high-density lipoprotein (HDL) (P= 0.02), higher low-density lipoprotein (LDL) particle number (P= 0.02), higher very low-density lipoprotein particle (VLDL) size (P= 0.03) and lower LDL (P= 0.03) and HDL particle size (P= 0.005) compared with non-Hispanic white women. The differences in HDL, HOMA-IR, VLDL and LDL size did not persist after adjustment for WHR while differences in LDL particle number (P= 0.04) and HDL size (P= 0.01) persisted.LIMITATIONS, REASON FOR CAUTIONThe sample size for the three groups was small but the findings were still significant. The women were mostly obese so the ethnic differences in metabolic disorders may not apply to non-obese women with PCOS.WIDER IMPLICATIONS OF THE FINDINGSIndependent of BMI, obese, reproductive age, Hispanic women with PCOS in the USA had a greater degree of abdominal obesity, insulin resistance and dyslipidemia. Hispanic women with PCOS may benefit from more focused management of metabolic parameters.STUDY FUNDING/COMPETING INTEREST(S)This project was supported by the following National Institutes of Health grants: K23 DK080988-01A1 to S.S. and UL1RR029879 to CTSA at University of Illinois. None of the authors report any conflict of interests.
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影响因子：
9.3
作者：
Chen BH;Brennan K;Goto A;Song Y;Aziz N;You NC;Wellons MF;Manson JE;White DL;Butch AW;Liu S
通讯作者：
Liu S
影响因子：
16.2
作者：
St-Onge, MP;Janssen, I;Heymsfield, SB
通讯作者：
Heymsfield, SB
影响因子：
5.9
作者：
Legro, RS;Kunselman, AR;Dunaif, A
通讯作者：
Dunaif, A
DOI：
10.1001/jama.1996.03540110029028
发表时间：
1996-09
期刊：
JAMA
影响因子：
--
作者：
C. Gardner;S. Fortmann;R. Krauss
通讯作者：
C. Gardner;S. Fortmann;R. Krauss
影响因子：
7.7
作者：
Garvey, WT;Kwon, S;Liao, YL
通讯作者：
Liao, YL