Cell- and gene-based therapeutic strategies for periodontal regenerative medicine.
Cell- and gene-based therapeutic strategies for periodontal regenerative medicine.
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DOI：
10.1902/jop.2011.100710
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发表时间：
2011-09
影响因子：
4.3
通讯作者：
Giannobile WV
中科院分区：
文献类型：
--
作者：
Rios HF;Lin Z;Oh B;Park CH;Giannobile WV
炎症性牙周病是牙齿脱落的主要原因，并与多种全身性疾病有关，如心血管疾病和中风。重建受影响的牙齿支持组织的支持和功能是牙周再生医学的一个重要治疗终点。随着对牙周生物学的进一步了解以及目前支架基质的进展，引入了使用细胞和基因治疗来增强牙周组织重建及其生物力学整合的新治疗方法。细胞和基因递送技术有可能克服与现有牙周治疗相关的局限性，并可能为可持续的炎症控制和支持牙槽骨、牙周韧带和牙骨质的更可预测的组织再生提供新的方向。本文综述了牙周再生医学中这些早期和新兴的基于细胞和基因的治疗方法的现状，并介绍了它们在临床牙周治疗中的未来应用。最后，对细胞和基因组织工程技术在牙周病重建中的应用前景进行了展望。
Inflammatory periodontal diseases are a leading cause of tooth loss and are linked to multiple systemic conditions, such as cardiovascular disease and stroke. Reconstruction of the support and function of affected tooth-supporting tissues represents an important therapeutic endpoint for periodontal regenerative medicine. An improved understanding of periodontal biology coupled with current advances in scaffolding matrices has introduced novel treatments that use cell and gene therapy to enhance periodontal tissue reconstruction and its biomechanical integration. Cell and gene delivery technologies have the potential to overcome limitations associated with existing periodontal therapies, and may provide a new direction in sustainable inflammation control and more predictable tissue regeneration of supporting alveolar bone, periodontal ligament, and cementum. This review provides clinicians with the current status of these early-stage and emerging cell- and gene-based therapeutics in periodontal regenerative medicine, and introduces their future application in clinical periodontal treatment. The paper concludes with prospects on the application of cell and gene tissue engineering technologies for reconstructive periodontology.
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影响因子：
--
作者：
Dogan, A;Özdemir, A;Oygür, T
通讯作者：
Oygür, T
影响因子：
5.1
作者：
通讯作者：
--
影响因子：
7.6
作者：
Alsberg, E;Kong, HJ;Mooney, DJ
通讯作者：
Mooney, DJ
影响因子：
1.5
作者：
Cong Toai Tran;Gargiulo, Ciro;Strong, D. Michael
通讯作者：
Strong, D. Michael
DOI：
10.1126/science.1171643
发表时间：
2009-06-26
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Discher DE;Mooney DJ;Zandstra PW
通讯作者：
Zandstra PW