Disruption of functional networks in dyslexia: a whole-brain, data-driven analysis of connectivity.
Disruption of functional networks in dyslexia: a whole-brain, data-driven analysis of connectivity.
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DOI：
10.1016/j.biopsych.2013.08.031
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发表时间：
2014-09-01
影响因子：
10.6
通讯作者：
Constable, R. Todd
中科院分区：
文献类型：
--
作者：
Finn, Emily S.;Shen, Xilin;Holahan, John M.;Scheinost, Dustin;Lacadie, Cheryl;Papademetris, Xenophon;Shaywitz, Sally E.;Shaywitz, Bennett A.;Constable, R. Todd
功能磁共振成像数据的功能连接分析是表征大脑网络以及它们在神经疾病中如何被破坏的强大工具。然而，许多这样的分析仅检查一个或少量的先验种子区域。考虑整个大脑的研究经常依赖于解剖图谱来定义网络节点，这可能导致在单个节点内混合不同的激活时间过程。在这里，我们改进了以前的方法，通过使用数据驱动的大脑分割，比较阅读障碍（DYS）与非受损（NI）的读者在第一个全脑功能连接分析的阅读障碍的连接配置文件。在儿童（n = 75; 43 NI，32 DYS）和成人（n = 104; 64 NI，40 DYS）读者中评估了全脑连接。与NI阅读者相比，DYS阅读者在视觉通路内以及视觉关联区和前额叶注意区之间表现出发散性连接;右半球连接增加;视觉词形区（左侧梭状回的一部分专门用于印刷文字）的连接减少;以及与额下回周围的前语言区域的持续连接。总之，研究结果表明，NI读者能够更好地整合视觉信息和调节他们的注意力，视觉刺激，让他们认识到他们的视觉特性的基础上的话，而DYS读者招募改变阅读电路，并依靠费力的语音为基础的“探测”到成年的战略。这些结果加深了我们对阅读障碍的神经基础的理解，并强调了不同大脑区域之间的同步对于成功阅读的重要性。
Functional connectivity analyses of fMRI data are a powerful tool for characterizing brain networks and how they are disrupted in neural disorders. However, many such analyses examine only one or a small number of a priori seed regions. Studies that consider the whole brain frequently rely on anatomic atlases to define network nodes, which may result in mixing distinct activation timecourses within a single node. Here, we improve upon previous methods by using a data-driven brain parcellation to compare connectivity profiles of dyslexic (DYS) versus non-impaired (NI) readers in the first whole-brain functional connectivity analysis of dyslexia. Whole-brain connectivity was assessed in children (n = 75; 43 NI, 32 DYS) and adult (n = 104; 64 NI, 40 DYS) readers. Compared to NI readers, DYS readers showed divergent connectivity within the visual pathway and between visual association areas and prefrontal attention areas; increased right-hemisphere connectivity; reduced connectivity in the visual word-form area (part of the left fusiform gyrus specialized for printed words); and persistent connectivity to anterior language regions around the inferior frontal gyrus. Together, findings suggest that NI readers are better able to integrate visual information and modulate their attention to visual stimuli, allowing them to recognize words based on their visual properties, while DYS readers recruit altered reading circuits and rely on laborious phonology-based “sounding out” strategies into adulthood. These results deepen our understanding of the neural basis of dyslexia and highlight the importance of synchrony between diverse brain regions for successful reading.
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影响因子：
5.7
作者：
Alexander-Bloch, Aaron;Lambiotte, Renaud;Roberts, Ben;Giedd, Jay;Gogtay, Nitin;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
1.5
作者：
Germano, Eva;Gagliano, Antonella;Curatolo, Paolo
通讯作者：
Curatolo, Paolo
影响因子：
2.6
作者：
Kronbichler, Martin;Hutzler, Florian;Wimmer, Heinz
通讯作者：
Wimmer, Heinz
影响因子：
3.6
作者：
Facoetti, A;Paganoni, P;Mascetti, GG
通讯作者：
Mascetti, GG
影响因子：
5.7
作者：
Hampson, Michelle;Tokoglu, Fuyuze;Constable, R. Todd
通讯作者：
Constable, R. Todd