Altered thalamic connectivity in insomnia disorder during wakefulness and sleep.
Altered thalamic connectivity in insomnia disorder during wakefulness and sleep.
复制标题
失眠症在清醒和睡眠期间丘脑连接的改变
DOI：
10.1002/hbm.25221
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发表时间：
2021-01
影响因子：
4.8
通讯作者：
Gao JH
中科院分区：
文献类型：
--
作者：
Zou G;Li Y;Liu J;Zhou S;Xu J;Qin L;Shao Y;Yao P;Sun H;Zou Q;Gao JH
失眠障碍是最常见的睡眠障碍，受到了越来越多的关注。许多研究表明，过度觉醒在失眠障碍的病理生理学中起着关键作用。然而，失眠障碍背后的具体大脑机制仍不清楚。为了阐明失眠障碍的神经病理生理学，我们研究了失眠障碍患者和健康对照者在睡眠 - 觉醒周期中的大脑功能网络。分析了33例失眠障碍患者和31例匹配良好的健康对照者在清醒和非快速眼动睡眠（包括N1、N2和N3阶段）期间的脑电图 - 功能性磁共振成像数据。考虑到丘脑内侧和前部区域在睡眠 - 觉醒调节中的作用，选择该区域作为种子点。计算了丘脑种子点与全脑体素之间的功能连接性。对基于丘脑的功能连接性进行了包含“组别”和“阶段”因素的方差分析。探索了错误感知指数与改变的功能连接性之间的相关性。在广泛的皮质区域观察到了组别与阶段的交互作用。就组别主效应而言，失眠障碍患者在清醒和所有三个非快速眼动睡眠阶段，丘脑与左侧杏仁核、海马旁回、壳核、苍白球和海马的连接性均降低。N1阶段皮质下集群和右侧颞叶集群的丘脑连接性与错误感知指数显著相关。这项研究展示了失眠障碍的大脑功能基础，并阐明了其与睡眠错误感知的关系，为失眠障碍的大脑机制提供了新的见解，并指出了其治疗的潜在靶点。
分析了失眠障碍患者和健康对照者在清醒和睡眠期间基于丘脑的连接性。在广泛的皮质区域观察到了组别与阶段的交互作用。就组别主效应而言，失眠障碍患者在清醒和所有三个非快速眼动睡眠阶段，丘脑与左侧杏仁核、海马旁回、壳核、苍白球和海马的连接性均降低。
Insomnia disorder is the most common sleep disorder and has drawn increasing attention. Many studies have shown that hyperarousal plays a key role in the pathophysiology of insomnia disorder. However, the specific brain mechanisms underlying insomnia disorder remain unclear. To elucidate the neuropathophysiology of insomnia disorder, we investigated the brain functional networks of patients with insomnia disorder and healthy controls across the sleep–wake cycle. EEG‐fMRI data from 33 patients with insomnia disorder and 31 well‐matched healthy controls during wakefulness and nonrapid eye movement sleep, including N1, N2 and N3 stages, were analyzed. A medial and anterior thalamic region was selected as the seed considering its role in sleep–wake regulation. The functional connectivity between the thalamic seed and voxels across the brain was calculated. ANOVA with factors “group” and “stage” was performed on thalamus‐based functional connectivity. Correlations between the misperception index and altered functional connectivity were explored. A group‐by‐stage interaction was observed at widespread cortical regions. Regarding the main effect of group, patients with insomnia disorder demonstrated decreased thalamic connectivity with the left amygdala, parahippocampal gyrus, putamen, pallidum and hippocampus across wakefulness and all three nonrapid eye movement sleep stages. The thalamic connectivity in the subcortical cluster and the right temporal cluster in N1 was significantly correlated with the misperception index. This study demonstrated the brain functional basis in insomnia disorder and illustrated its relationship with sleep misperception, shedding new light on the brain mechanisms of insomnia disorder and indicating potential therapeutic targets for its treatment.
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DOI：
10.1016/j.nicl.2017.07.008
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bagshaw AP;Hale JR;Campos BM;Rollings DT;Wilson RS;Alvim MKM;Coan AC;Cendes F
通讯作者：
Cendes F
DOI：
10.1523/jneurosci.1809-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Cano G;Mochizuki T;Saper CB
通讯作者：
Saper CB
影响因子：
5.6
作者：
Hsiao, Fan-Chi;Tsai, Pei-Jung;Wu, Yu-Zu
通讯作者：
Wu, Yu-Zu
影响因子：
5.7
作者：
Hale, Joanne R.;White, Thomas P.;Bagshaw, Andrew P.
通讯作者：
Bagshaw, Andrew P.
影响因子：
5.7
作者：
Falahpour M;Chang C;Wong CW;Liu TT
通讯作者：
Liu TT