Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery.
Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery.
复制标题
猪冠状动脉两层模型中的被动和主动三轴壁力学。
DOI：
10.1038/s41598-017-14276-1
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发表时间：
2017-10-24
影响因子：
4.6
通讯作者：
Huo Y
中科院分区：
文献类型：
--
作者：
Lu Y;Wu H;Li J;Gong Y;Ma J;Kassab GS;Huo Y;Tan W;Huo Y
冠状动脉的三轴主动和被动力学特性需要了解健康和疾病中的动脉力学。研究的目的是量化主动和被动应变能函数在周向，轴向和径向方向的实验测量的基础上。此外，使用双层计算模型来确定跨血管壁的应力和应变的跨壁分布。在三个法向上的第一Piola-Kirchhoff应力具有近似关系：双层模型显示，从内膜层到中膜和外膜层之间的界面，周向柯西应力显著增加（从~80 kPa到160 kPa），在界面处突然下降（从~160 kPa到<5 kPa），并朝向外膜层的外边界略微增加。相反，径向柯西应力的绝对值从血管壁的内边界到外边界连续减小（从~11 kPa到零）。平滑肌细胞收缩显著增加了内膜-中层的径向与周向柯西应力的比值，其在内膜层具有最高值。
Triaxial active and passive mechanical properties of coronary arteries are needed for understanding arterial mechanics in health and disease. The aim of the study was to quantify both active and passive strain energy functions in circumferential, axial and radial directions based on the experimental measurement. Moreover, a two-layer computational model was used to determine the transmural distribution of stresses and strains across the vessel wall. The first Piola-Kirchhoff stresses in the three normal directions had the approximate relationship as:. The two-layer model showed that circumferential Cauchy stresses increased significantly from the intima layer to the interface between media and adventitia layers (from ~80 to 160 kPa), dropped abruptly at the interface (from ~160 to <5 kPa), and increased slightly towards the outer boundary of the adventitia layer. In contrast, absolute values of radial Cauchy stress decreased continuously from the inner to outer boundaries of the vessel wall (from ~11 kPa to zero). Smooth muscle cell contraction significantly increased the ratio of radial to circumferential Cauchy stresses at the intima-media layer, which had the highest values at the intima layer.
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影响因子：
2.4
作者：
Chen H;Kassab GS
通讯作者：
Kassab GS
影响因子：
2.4
作者：
Rachev, A
通讯作者：
Rachev, A
影响因子：
2.7
作者：
LIU, DC;NOCEDAL, J
通讯作者：
NOCEDAL, J
影响因子：
14
作者：
Chen, Huan;Luo, Tong;Zhao, Xuefeng;Lu, Xiao;Huo, Yunlong;Kassab, Ghassan S.
通讯作者：
Kassab, Ghassan S.
DOI：
10.1152/ajpheart.00491.2001
发表时间：
2002-06-01
影响因子：
4.8
作者：
Cornelissen, AJM;Dankelman, J;Spaan, JAE
通讯作者：
Spaan, JAE