GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor.
GATA4 immunolocalization in breast carcinoma as a potent prognostic predictor.
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DOI：
10.1111/cas.12382
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发表时间：
2014-05
期刊：
影响因子：
5.7
通讯作者：
Suzuki T
中科院分区：
文献类型：
--
作者：
Takagi K;Moriguchi T;Miki Y;Nakamura Y;Watanabe M;Ishida T;Yamamoto M;Sasano H;Suzuki T
转录 GATA 因子是已知的谱系选择基因，调节多种生物过程，包括组织的规范和分化。在本研究中，我们使用微阵列分析（n = 20）检查了乳腺癌浸润性导管癌（IDC）中六个 GATA 因子基因的表达谱，发现 GATA4 表达与患者的复发密切相关。由于 GATA4 在乳腺癌中的意义在很大程度上仍不清楚，因此我们进一步对乳腺导管原位癌 (DCIS) (n = 48) 和 IDC (n = 163) 中的 GATA4 进行免疫定位。在癌细胞的细胞核中检测到 GATA4 免疫反应性，在 27% 的 DCIS 和 31% 的 IDC 病例中呈阳性。 GATA4状态与DCIS中的核分级和van Nuys分类显着相关，与远处转移、组织学分级和HER2状态呈正相关，但与IDC中的孕酮受体标记指数呈负相关。随后的多变量分析表明，GATA4 状态是 IDC 患者无病生存和乳腺癌特异性生存的独立预后因素。所有这些结果表明，GATA4 在乳腺癌的早期进展中发挥着重要作用，免疫组织化学 GATA4 状态被认为是人类乳腺癌患者的有效预后因素。
Transcriptional GATA factors are known lineage selector genes and regulate a variety of biological processes including specification and differentiation of tissues. In the present study, we examined expression profiles of six GATA factor genes in invasive ductal carcinomas (IDC) of the breast using microarray analysis (n = 20) and found that GATA4 expression was closely correlated with recurrence in patients. Because the significance of GATA4 has remained largely unknown in breast carcinoma, we further immunolocalized GATA4 in ductal carcinoma in situ (DCIS) of the breast (n = 48) and IDC (n = 163). GATA4 immunoreactivity was detected in the nuclei of carcinoma cells and was positive in 27% of DCIS and 31% of IDC cases. GATA4 status was significantly associated with nuclear grade and van Nuys classification in DCIS and was positively associated with distant metastasis, histological grade and HER2 status, but negatively correlated with progesterone receptor labeling index in IDC. Subsequent multivariate analysis demonstrated that GATA4 status was an independent prognostic factor for both disease-free and breast cancer-specific survival of IDC patients. All of these results indicate that GATA4 plays important roles in the progression of breast carcinoma from an early stage and that immunohistochemical GATA4 status is considered a potent prognostic factor in human breast cancer patients.
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影响因子：
3.6
作者：
Freudenberg, Jaclyn A.;Wang, Qiang;Katsumata, Makoto;Drebin, Jeffrey;Nagatomo, Izumi;Greene, Mark I.
通讯作者：
Greene, Mark I.
影响因子：
14.9
作者：
Bresnick EH;Katsumura KR;Lee HY;Johnson KD;Perkins AS
通讯作者：
Perkins AS
影响因子：
64.5
作者：
Kouros-Mehr, Hosein;Slorach, Euan M.;Werb, Zena
通讯作者：
Werb, Zena
影响因子：
5.3
作者：
ARCECI, RJ;KING, AAJ;WILSON, DB
通讯作者：
WILSON, DB
影响因子：
2.5
作者：
Acosta, Deanna;Suzuki, Masako;Montagna, Cristina
通讯作者：
Montagna, Cristina