Increased neural activity of a mushroom body neuron subtype in the brains of forager honeybees.
Increased neural activity of a mushroom body neuron subtype in the brains of forager honeybees.
复制标题
蘑菇体神经元亚型的神经活动增加了觅食蜜蜂的大脑。
DOI：
10.1371/journal.pone.0000371
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发表时间：
2007-04-18
期刊：
影响因子：
3.7
通讯作者：
Kubo, Takeo
中科院分区：
文献类型：
--
作者：
Kiya, Taketoshi;Kunieda, Takekazu;Kubo, Takeo
蜜蜂组织了一个复杂的社会，工蜂用一种象征性的舞蹈传递食物来源的位置信息，被称为“舞蹈交流”。最近的研究表明，工蜂在觅食飞行过程中整合感官信息进行舞蹈交流。然而，解释这种非凡能力的神经机制尚不清楚。在本研究中，我们建立了一种新的方法来可视化蜜蜂大脑中的神经活动，使用一种新的立即早期基因，kakusei，作为神经活动的标记。kakusei转录本定位于脑神经元的核中，并且不编码开放阅读框架，这表明它作为非编码核RNA发挥作用。使用这种方法，我们表明，蘑菇体神经元亚型，小型凯尼恩细胞的神经活动显着增加的舞蹈家和觅食蜜蜂的大脑。相比之下，两种蘑菇体神经元亚型（小型和大型凯尼恩细胞）的神经活动在重新定向工人的大脑中增加，这些工人在重新定向飞行期间记住了他们的蜂巢位置。这些研究结果表明，小型凯尼恩细胞的优先活动与觅食行为，这表明它参与觅食飞行过程中的信息整合，这是舞蹈沟通的重要基础。
Honeybees organize a sophisticated society, and the workers transmit information about the location of food sources using a symbolic dance, known as ‘dance communication’. Recent studies indicate that workers integrate sensory information during foraging flight for dance communication. The neural mechanisms that account for this remarkable ability are, however, unknown. In the present study, we established a novel method to visualize neural activity in the honeybee brain using a novel immediate early gene, kakusei, as a marker of neural activity. The kakusei transcript was localized in the nuclei of brain neurons and did not encode an open reading frame, suggesting that it functions as a non-coding nuclear RNA. Using this method, we show that neural activity of a mushroom body neuron subtype, the small-type Kenyon cells, is prominently increased in the brains of dancer and forager honeybees. In contrast, the neural activity of the two mushroom body neuron subtypes, the small-and large-type Kenyon cells, is increased in the brains of re-orienting workers, which memorize their hive location during re-orienting flights. These findings demonstrate that the small-type Kenyon cell-preferential activity is associated with foraging behavior, suggesting its involvement in information integration during foraging flight, which is an essential basis for dance communication.
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