Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma.
Cost effectiveness of vitamin c supplementation for pregnant smokers to improve offspring lung function at birth and reduce childhood wheeze/asthma.
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DOI：
10.1038/s41372-018-0135-6
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Dukhovny D
中科院分区：
文献类型：
--
作者：
Yieh L;McEvoy CT;Hoffman SW;Caughey AB;MacDonald KD;Dukhovny D
确定补充维生素C对孕妇吸烟者的影响及其对儿童哮喘患病率、哮喘相关死亡率和相关成本的影响。通过TreeAge建立的决策分析模型比较了怀孕吸烟者18年所生的48万名儿童的理论年度队列中哮喘的结果。将补充标准产前维生素的维生素C(500毫克/天)与产前补充维生素C(60毫克/天)进行比较。模型输入来自文献。确定性和概率性敏感性分析评估了假设的影响。怀孕期间补充维生素C将防止每一名怀孕吸烟者出生时18岁时患哮喘1637例。维生素C将减少与哮喘相关的儿童死亡，并在18年内为每个出生队列节省31,420,800美元的社会成本。对怀孕的吸烟者补充维生素C是一种安全和廉价的干预措施，可能会减轻儿童哮喘的经济负担。
To determine the implications of supplemental vitamin C for pregnant tobacco smokers and its effects on the prevalence of pediatric asthma, asthma-related mortality, and associated costs. A decision-analytic model built via TreeAge compared the outcome of asthma in a theoretical annual cohort of 480,000 children born to pregnant smokers through 18 years of life. Vitamin C supplementation (500 mg/day) with a standard prenatal vitamin was compared to a prenatal vitamin (60 mg/day). Model inputs were derived from the literature. Deterministic and probabilistic sensitivity analyses assessed the impact of assumptions. Additional vitamin C during pregnancy would prevent 1,637 cases of asthma at age 18 per birth cohort of pregnant smokers. Vitamin C would reduce asthma-related childhood deaths and save $31,420,800 in societal costs over 18 years per birth cohort. Vitamin C supplementation in pregnant smokers is a safe and inexpensive intervention that may reduce the economic burden of pediatric asthma.
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