Biohybrid nanostructured iron oxide nanoparticles and Satureja hortensis to prevent fungal biofilm development.
Biohybrid nanostructured iron oxide nanoparticles and Satureja hortensis to prevent fungal biofilm development.
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DOI：
10.3390/ijms140918110
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发表时间：
2013-09-04
影响因子：
5.6
通讯作者：
Chifiriuc MC
中科院分区：
文献类型：
--
作者：
Anghel I;Grumezescu AM;Holban AM;Ficai A;Anghel AG;Chifiriuc MC
在愈合过程中，皮肤伤口经常会受到双重感染，这会导致长时间的康复和不适。使用合适的伤口敷料对于适当的伤口护理非常重要，从而导致正确的愈合。本研究旨在证明纳米涂层伤口敷料（WD）对白色念珠菌定植率和生物膜形成的影响。通过将敷料片浸入由功能化磁铁矿纳米颗粒和Satureja hortensis（SO）精油（EO）组成的纳米流体中，实现了改性WD。通过GC-MS确定了EO的化学组成，并通过X射线衍射（XRD）、透射电子显微镜（TEM）、差热分析（DTA）和傅里叶变换红外光谱（FT-IR）对制备的纳米结构进行了表征。扫描电镜分析表明，C.与常规的未涂覆材料相比，在涂覆有所获得的纳米流体的伤口敷料纤维的表面上，白色念珠菌粘附和随后的生物膜发展被强烈抑制。结果也证实了包埋在生物膜中的活真菌细胞的测定。我们的数据表明，所获得的植物纳米涂层提高了伤口敷料表面对C。白色念珠菌定植，这通常是局部感染的病因，损害适当的伤口愈合。
Cutaneous wounds are often superinfected during the healing process and this leads to prolonged convalescence and discomfort. Usage of suitable wound dressings is very important for an appropriate wound care leading to a correct healing. The aim of this study was to demonstrate the influence of a nano-coated wound dressing (WD) on Candida albicans colonization rate and biofilm formation. The modified WD was achieved by submerging the dressing pieces into a nanofluid composed of functionalized magnetite nanoparticles and Satureja hortensis (SO) essential oil (EO). Chemical composition of the EO was established by GC-MS. The fabricated nanostructure was characterized by X-ray Diffraction (XRD), Transmission Electron Microscopy (TEM), Differential Thermal Analysis (DTA) and Fourier Transform-Infrared Spectroscopy (FT-IR). The analysis of the colonized surfaces using (Scanning Electron Microscopy) SEM revealed that C. albicans adherence and subsequent biofilm development are strongly inhibited on the surface of wound dressing fibers coated with the obtained nanofluid, comparing with regular uncoated materials. The results were also confirmed by the assay of the viable fungal cells embedded in the biofilm. Our data demonstrate that the obtained phytonanocoating improve the resistance of wound dressing surface to C. albicans colonization, which is often an etiological cause of local infections, impairing the appropriate wound healing.
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影响因子：
3.9
作者：
Grumezescu, Alexandru Mihai;Saviuc, Crina;Lazar, Veronica
通讯作者：
Lazar, Veronica
影响因子：
2.7
作者：
Maity, D.;Agrawal, D. C.
通讯作者：
Agrawal, D. C.
影响因子：
5.8
作者：
Masoudi, Afshin;Hosseini, Hamid Reza Madaah;Ahmadi, Reza
通讯作者：
Ahmadi, Reza
影响因子：
--
作者：
Chifiriuc C;Grumezescu V;Grumezescu AM;Saviuc C;Lazăr V;Andronescu E
通讯作者：
Andronescu E
影响因子：
5.8
作者：
Alphandery, Edouard;Guyot, Francois;Chebbi, Imene
通讯作者：
Chebbi, Imene