Oxytocin and social motivation.
Oxytocin and social motivation.
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DOI：
10.1016/j.dcn.2011.07.007
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发表时间：
2011-10
影响因子：
4.7
通讯作者：
Leckman, James F.
中科院分区：
文献类型：
--
作者：
Gordon, Ilanit;Martin, Carina;Feldman, Ruth;Leckman, James F.
关键词：
从根本上说，人类是社会性的动物，他们“有动机”与他人在一起。在这篇综述中，我们研究催产素（OT）的作用，因为它涉及到社会动机。OT在大脑和全身合成，包括心脏、胸腺、胃肠道以及生殖器官。OT受体（OTR）系统在大脑和外周的分布更为深远，其表达在发育过程中会发生变化。OTR表达对外部环境和内部体细胞世界的变化也很敏感。OT系统是一个复杂的、发育敏感的生物行为系统中的重要组成部分。其他要素包括感觉输入、显著性、奖励和威胁检测通路、下丘脑-垂体-性腺轴和下丘脑-垂体-肾上腺应激反应轴。尽管不断扩大的科学文献，关键的未解决的问题仍然是关于这个复杂的生物行为系统的中心和外围组件的相互作用，动态地参与大脑和身体作为人类与社会合作伙伴在发展过程中互动。
Humans are fundamentally social creatures who are ‘motivated’ to be with others. In this review we examine the role of oxytocin (OT) as it relates to social motivation. OT is synthesized in the brain and throughout the body, including in the heart, thymus, gastrointestinal tract, as well as reproductive organs. The distribution of the OT receptor (OTR) system in both the brain and periphery is even more far-reaching and its expression is subject to changes over the course of development. OTR expression is also sensitive to changes in the external environment and the internal somatic world. The OT system functions as an important element within a complex, developmentally sensitive biobehavioral system. Other elements include sensory inputs, the salience, reward, and threat detection pathways, the hypothalamic-pituitary-gonadal axis, and the hypothalamic-pituitary-adrenal stress response axis. Despite an ever expanding scientific literature, key unresolved questions remain concerning the interplay of the central and peripheral components of this complex biobehavioral system that dynamically engages the brain and the body as humans interact with social partners over the course of development.
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