Encoding of social exploration by neural ensembles in the insular cortex.
Encoding of social exploration by neural ensembles in the insular cortex.
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DOI：
10.1371/journal.pbio.3000584
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发表时间：
2020-09
期刊：
影响因子：
9.8
通讯作者：
Takumi T
中科院分区：
文献类型：
--
作者：
Miura I;Sato M;Overton ETN;Kunori N;Nakai J;Kawamata T;Nakai N;Takumi T
岛叶皮层（IC）参与各种复杂的脑功能，包括社会功能，但其细胞基础仍有待充分理解。使用显微镜钙成像的无颗粒岛叶皮质（AI）在小鼠与自由移动和限制的社会目标的相互作用，我们确定了AI神经元的2个子集-较大比例的“社会-ON”细胞和较小比例的“社会-OFF”细胞-在社会探索过程中改变他们的活动在相反的方向。社会-ON细胞包括那些代表独立于位置的社会调查的细胞，由多个子集组成，每个子集在特定行为状态下或与特定的身体接触目标进行探索期间优先活跃。这些结果揭示了AI神经元的一种以前未知的功能，这种功能可能会在动物与不熟悉的同种动物互动时监测社会探索的持续状态。岛叶皮质参与多种复杂的脑功能，包括社会功能，但其细胞基础尚不清楚。这项研究使用显微内窥镜钙成像在小鼠与同种相互作用，以确定“社会细胞”在无颗粒岛叶皮层;多个子集的神经元编码正在进行的社会行为的不同方面。
The insular cortex (IC) participates in diverse complex brain functions, including social function, yet their cellular bases remain to be fully understood. Using microendoscopic calcium imaging of the agranular insular cortex (AI) in mice interacting with freely moving and restrained social targets, we identified 2 subsets of AI neurons—a larger fraction of “Social-ON” cells and a smaller fraction of “Social-OFF” cells—that change their activity in opposite directions during social exploration. Social-ON cells included those that represented social investigation independent of location and consisted of multiple subsets, each of which was preferentially active during exploration under a particular behavioral state or with a particular target of physical contact. These results uncover a previously unknown function of AI neurons that may act to monitor the ongoing status of social exploration while an animal interacts with unfamiliar conspecifics. The insular cortex participates in diverse complex brain functions, including social function, but their cellular basis remains unclear. This study uses microendoscopic calcium imaging in mice interacting with conspecifics to identify “social cells” in the agranular insular cortex; multiple subsets of neurons encode distinct aspects of ongoing social behavior.
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