Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period.
Thyroid hormone insufficiency alters the expression of psychiatric disorder-related molecules in the hypothyroid mouse brain during the early postnatal period.
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甲状腺激素不足改变出生后早期甲状腺功能减退小鼠脑中精神障碍相关分子的表达。
DOI：
10.1038/s41598-021-86237-8
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发表时间：
2021-03-24
影响因子：
4.6
通讯作者：
Itoi K
中科院分区：
文献类型：
--
作者：
Uchida K;Hasuoka K;Fuse T;Kobayashi K;Moriya T;Suzuki M;Katayama N;Itoi K
本研究探讨了甲状腺激素(TH)在小鼠大脑皮质和海马神经元发育过程中的功能作用。TH缺乏表现为出生后14d幼鼠大脑皮质和海马区小白蛋白(PV)的表达减少，而从PD0到PD14的甲状腺素治疗改善了小白蛋白的表达。另一方面，成年后接受抗甲状腺药物治疗并没有导致这些区域PV表达的减少。这些结果表明，在出生后早期存在TH作用的临界期。大脑皮层II-IV层MeCP2阳性神经元核团也明显减少。与正常小鼠相比，甲状腺功能减退小鼠躯体感觉皮质中的CUX1信号减少，皮质II-IV层总厚度低于正常小鼠。这些结果表明，围产期TH不足对神经元发育有强烈而广泛的影响。
The functional role of thyroid hormone (TH) in the cortex and hippocampus of mouse during neuronal development was investigated in this study. TH insufficiency showed a decrease in the expression of parvalbumin (PV) in the cortex and hippocampus of pups at postnatal day (PD) 14, while treatment with thyroxine from PD 0 to PD 14 ameliorated the PV loss. On the other hand, treatment with antithyroid agents in adulthood did not result in a decrease in the expression of PV in these areas. These results indicate the existence of a critical period of TH action during the early postnatal period. A decrease in MeCP2-positive neuronal nuclei was also observed in the cortical layers II–IV of the cerebral cortex. The brains were then stained with CUX1, a marker for cortical layers II–IV. In comparison with normal mice, CUX1 signals were decreased in the somatosensory cortex of the hypothyroid mice, and the total thickness of cortical layers II–IV of the mice was lower than that of normal mice. These results suggest that TH insufficiency during the perinatal period strongly and broadly affects neuronal development.
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影响因子：
2.5
作者：
Hadj-Sahraoui, N;Seugnet, I;Demeneix, B
通讯作者：
Demeneix, B
影响因子：
--
作者：
COOKE, DW;NAIDU, S;BERKOVITZ, GD
通讯作者：
BERKOVITZ, GD
影响因子：
5.1
作者：
de Souza, Janaina Sena;Ferreira, Divino Romao;Giannocco, Gisele
通讯作者：
Giannocco, Gisele
影响因子：
2.5
作者：
CAVINESS, VS;SIDMAN, RL
通讯作者：
SIDMAN, RL
影响因子：
2.5
作者：
Berbel, P;Marco, P;DeFelipe, J
通讯作者：
DeFelipe, J